Tocofersolan

CAS: 9002-96-4

Ref. TR-T526075

Product Information

• Name: Tocofersolan
• Synonyms: D 1T, Vitamin E Polyethylene Glycol Succinate, Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] Succinate Polyoxyethylene Ether, TPGS, Tocophersolan, Vitamin E-TPGS,[2R-[2R*(4R*,8R*)]]-α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxypoly(oxy-1,2-ethanediyl), D-α-Tocopherol Polyethylene Glycol 1000 Succinate, 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl butanedioate, <span class="text-smallcaps">D</span>-α-Tocopherol acid polyethylene glycol 1000 succinate, <span class="text-smallcaps">D</span>-α-Tocopherol polyethylene glycol 1000 succinate, <span class="text-smallcaps">D</span>-α-Tocopheryl polyethylene glycol succinate, Eastman Vitamin ETPGS, Ethoxylated vitamin E succinate, Kolliphor TPGS, Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] succinate, polyoxyethylene ether, Poly(oxy-1,2-ethanediyl), α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-, Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-, [2R-[2R*(4R*,8R*)]]-, Polyethylene glycol vitamin E succinate, Speziol TPGS Pharma, Tpgs 1000, Tpgs 1500, Tpgs 400-1000, Tpgs-Ve, Ve-Tpgs 1000, Vedrop, VitE-TPGS, Vitamin E-TPGS, d-α-Tocopheryl poly(ethylene glycol) 1000 succinate, d-α-Tocopheryl polyethylene glycol succinate, α-Tocopherol polyethylene glycol succinate, α-Tocopheryl polyethylene glycol succinate
• CAS: 9002-96-4

Description

Applications Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
References Socha, P. et al.: J. Pediatric Gastroenterol. Nutr., 24, 189 (1997); Chang, T. et al.: Clin. Pharmacol. Therap., 59, 297 (1996); Wu, S.H.W. et al.: Pharmac. Technol., 23, 52 (1999);

• Brand: TRC

Chemical properties

• Molecular weight: 530.78 + (44.05)n
• Formula: C₃₃H₅₄O₅(C₂H₄O)n
• Color/Form: White to Pale Yellow Waxy Solid
• InChI: InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3/t25-,26-,35-/m1/s1
• InChI key: InChIKey=AOBORMOPSGHCAX-AZAGJHQNSA-N
• SMILES: Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)OCCO)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2