Topotecan Carboxylic Acid Sodium Salt

CAS: 123949-08-6

Ref. TR-T542510

Product Information

• Name: Topotecan Carboxylic Acid Sodium Salt
• Synonyms: 1-[(Dimethylamino)methyl]-α-ethyl-9,11-dihydro-α,2-dihydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt, 1-[(Dimethylamino)methyl]-a-ethyl-9,11-dihydro-a,2-dihydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic Acid Monosodium Salt

Description

Applications The novel carboxylate metabolite of Topotecan.
References Liu, L., et al.: Annu. Rev. Biochem., 58, 351 (1989),Underberg, W., et al.: J. Pharm. Biomed. Anal., 8, 681 (1990), Grochow, L., et al.: Drug Metab. Dispos., 20, 706 (1992), Scott, D., et al.: Pharm. Res., 10, 1451 (1993),

• Brand: TRC

Chemical properties

• Molecular weight: 461.44
• Formula: C₂₃H₂₄N₃NaO₆
• Color/Form: Orange to Dark Orange Solid
• InChI: InChI=1S/C23H25N3O6.Na/c1-12-16(23(32,6-7-27)22(30)31)9-18-20-13(10-26(18)21(12)29)8-14-15(11-25(2)3)19(28)5-4-17(14)24-20;/h4-5,8-9,27-28,32H,6-7,10-11H2,1-3H3,(H,30,31);/q;+1/p-1/t23-;/m0./s1
• InChI key: InChIKey=MKNSEUWGSSBVQF-UHFFFAOYSA-M
• SMILES: CCC(O)(C(=O)O[Na])c1cc2n(c(=O)c1CO)Cc1cc3c(CN(C)C)c(O)ccc3nc1-2