3,3’,5-Triiodo-L-thyronine Methyl Ester Trifluoroacetamide

CAS: 3006-04-0

Ref. TR-T795403

Product Information

• Name: 3,3’,5-Triiodo-L-thyronine Methyl Ester Trifluoroacetamide
• Synonyms: (S)-Methyl 3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-2-(2,2,2-trifluoroacetamido)propanoate, L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-N-(trifluoroacetyl)-alanine Methyl Ester
• CAS: 3006-04-0

Description

Applications 3,3’,5-Triiodo-L-thyronine Methyl Ester Trifluoroacetamide is an intermediate in synthesizing 3,3’,5-Triiodo-L-thyronine O-β-D-Glucuronide (T795405), a O-glucuronide derivative of 3,3’,5-Triiodo-L-thyronine (T795380); one of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
References Gross, J., et al.: Lancet I, 439 (1952); Roche, J., et al.: Biochim. Biophys. Acta, 11, 215 (1953); Chacon, M.A., et al.: J. Pediatr., 99, 758 (1981); Chopra, I.J., et al.: Thyroid, 6, 255 (1996)

• Brand: TRC

Chemical properties

• Molecular weight: 761.008
• Formula: C₁₈H₁₃F₃I₃NO₅
• Color/Form: Yellow Solid
• InChI: InChI=1S/C18H13F3I3NO5/c1-29-16(27)13(25-17(28)18(19,20)21)6-8-4-11(23)15(12(24)5-8)30-9-2-3-14(26)10(22)7-9/h2-5,7,13,26H,6H2,1H3,(H,25,28)/t13-/m0/s1
• InChI key: InChIKey=SHCRKLCIFKMVGW-ZDUSSCGKSA-N
• SMILES: COC(=O)[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)NC(=O)C(F)(F)F