TSU-68

CAS: 252916-29-3

Ref. TR-T797550

Product Information

• Name: TSU-68
• Synonyms: 3-[2,4-Dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propionic Acid, 3-[4-(2-Carboxyethyl)-3,5-dimethylpyrrol-2-methylidenyl]-2-indolinone, 5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid, NSC 702827, Orantinib, SU 6668, 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, 3-[2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic acid, 3-[2,4-Dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propionic acid, 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid, 3-{2,4-dimethyl-5-[(E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Su-6668, Tsu-68
• CAS: 252916-29-3

Description

Applications TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 towards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.
References Pandey, A.L., et al.: Med. Chem. Rsch., 2, 3958 (2012); Mahasenan, K.V., et al.: J. Chem. Info. Modeling., 52, 1345 (2012).

• Brand: TRC

Chemical properties

• Molecular weight: 310.35
• Formula: C₁₈H₁₈N₂O₃
• Color/Form: Orange to Brown Solid
• InChI: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+
• InChI key: InChIKey=NHFDRBXTEDBWCZ-NTEUORMPSA-N
• SMILES: Cc1[nH]c(C=C2C(O)=Nc3ccccc32)c(C)c1CCC(=O)O