N-(1S,2S,3R,4S)-2,3,4-Tris(benzyloxy)-1-((benzyloxy)methyl)cyclohexanol (1S,2S,3R,4S,5S)-2,3,4-Tris(benzyloxy)-5-(((R)-1-(benzyloxy)-3-hydroxypropan-2-yl)amino)-1-((benzyloxy)methyl)cyclohexanol

CAS: 2415029-64-8

Ref. TR-T886490

Product Information

• Name: N-(1S,2S,3R,4S)-2,3,4-Tris(benzyloxy)-1-((benzyloxy)methyl)cyclohexanol (1S,2S,3R,4S,5S)-2,3,4-Tris(benzyloxy)-5-(((R)-1-(benzyloxy)-3-hydroxypropan-2-yl)amino)-1-((benzyloxy)methyl)cyclohexanol

Description

Applications N-(1S,2S,3R,4S)-2,3,4-Tris(benzyloxy)-1-((benzyloxy)methyl)cyclohexanol (1S,2S,3R,4S,5S)-2,3,4-Tris(benzyloxy)-5-(((R)-1-(benzyloxy)-3-hydroxypropan-2-yl)amino)-1-((benzyloxy)methyl)cyclohexanol is an intermediate of (R)-Valiolamine Voglibose Dihydrochloride (V094390). (R)-Valiolamine Voglibose is the main R-enantiomeric intermediate of Voglibose (V750000), an α-glucosidase inhibitor that works by delaying the digestion and absorption of carbohydrates, thereby inhibiting postprandial hyperglycemia and hyperinsulinemia.
References Chen, X.L., et al.: Curr. Med. Chem., 13, 109 (2006);

• Brand: TRC

Chemical properties

• Molecular weight: 1253.56
• Formula: C₈₀H₈₈N₂O₁₁
• Color/Form: Neat
• InChI: InChI=1S/C80H88N2O11/c83-79(59-86-50-62-30-12-2-13-31-62)46-71(73(88-52-64-34-16-4-17-35-64)75(90-54-66-38-20-6-21-39-66)77(79)92-56-68-42-24-8-25-43-68)81-48-70(58-85-49-61-28-10-1-11-29-61)82-72-47-80(84,60-87-51-63-32-14-3-15-33-63)78(93-57-69-44-26-9-27-45-69)76(91-55-67-40-22-7-23-41-67)74(72)89-53-65-36-18-5-19-37-65/h1-45,70-78,81-84H,46-60H2/t70-,71+,72+,73?,74?,75?,76?,77?,78?,79+,80+/m1/s1
• SMILES: O[C@]1(COCc2ccccc2)C[C@H](N[C@H](CN[C@@H]2C[C@@](O)(COCc3ccccc3)[C@H](OCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)COCc2ccccc2)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1