Estimated delivery in United States, on Tuesday 25 Jun 2024
Product Information
Name:
VX 745
Synonyms:
- 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
- 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one
- 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
- 6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-
- Neflamapimod
- Vd 31745
- Vrt 031745
- Vx-745
CAS:
Description:
Applications VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
References Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
436.26
Formula:
C19H9Cl2F2N3OS
Color/Form:
Neat
InChI:
InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key:
InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N
SMILES:
O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl
MDL:
Melting point:
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Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-V900500 VX 745
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