CAS 1016543-77-3

Fórmula: C21H19N5O4S

InChI: InChI=1S/C21H19N5O4S/c1-28-17-7-13(8-18(29-2)20(17)30-3)19(27)14-5-4-12(15-9-31-21(22)25-15)6-16(14)26-11-23-10-24-26/h4-11H,1-3H3,(H2,22,25)

Chave InChI: OJZSPKKXYGZDRQ-UHFFFAOYSA-N

SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)C2=C(C=C(C=C2)C3=CSC(=N3)N)N4C=NC=N4

S516

CAS: 1016543-77-3

Fórmula: C₂₁H₁₉N₅O₄S

Pureza: 98.03%

Peso molecular: 437.4717

Ref: IN-DA01V69O

S516

CAS: 1016543-77-3

S516

Fórmula: C₂₁H₁₉N₅O₄S

Pureza: ≥95%

Peso molecular: 437.47

Ref: 54-OR1134697

S516

CAS: 1016543-77-3

S516 is a potent anticancer agent that inhibits homologous recombination repair. It has been shown to have anti-tumor activity in vivo and in vitro. S516 has also been found to inhibit tumor vasculature, which may be due to its ability to induce the polymerization of DNA or its methylation by arginine. S516 is a polycyclic compound with a carbonyl group at position 516, which can form covalent bonds with the reactive groups on DNA during polymerization. The inhibition of homologous recombination repair leads to the accumulation of unrepaired double-stranded DNA breaks, leading to cell death.

Fórmula: C₂₁H₁₉N₅O₄S

Pureza: Min. 95%

Peso molecular: 437.5 g/mol

Ref: 3D-RQB54377

S516

CAS: 1016543-77-3

S516 is an active CKD-516 metabolite and a tubulin polymerization inhibitor (IC₅₀=4.29 μM) with potent antitumor activity.

Fórmula: C₂₁H₁₉N₅O₄S

Pureza: 97.44%

Cor e Forma: Solid

Peso molecular: 437.472

Ref: TM-T12823