CAS 1046447-90-8

Fórmula: C11H19N5

InChI: InChI=1S/C11H19N5/c1-7(2)9-5-10(15-11(13)14-9)16-4-3-8(12)6-16/h5,7-8H,3-4,6,12H2,1-2H3,(H2,13,14,15)/t8-/m1/s1

Chave InChI: COOGVHJHSCBOQT-MRVPVSSYSA-N

SMILES: CC(C)C1=CC(=NC(=N1)N)N2CC[C@H](C2)N

JNJ-39758979

CAS: 1046447-90-8

JNJ-39758979: selective H4 receptor antagonist, Kis 12.5/5.3/25 nM (human/mouse/monkey), blocks histamine cAMP inhibition (pA2 7.9).

Fórmula: C₁₁H₁₉N₅

Pureza: 98.33% - 99.62%

Cor e Forma: Solid

Peso molecular: 221.3

Ref: TM-T11723L

JNJ-39758979

CAS: 1046447-90-8

JNJ-39758979

Fórmula: C₁₁H₁₉N₅

Pureza: ≥98%

Peso molecular: 221.3

Ref: 54-BUP12890

JNJ-39758979

CAS: 1046447-90-8

(R)-4-(3-Aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine

Fórmula: C₁₁H₁₉N₅

Pureza: 98%

Peso molecular: 221.3

Ref: IN-DG758092

JNJ 39758979 TFA Salt

Produto Controlado

CAS: 1046447-90-8

Applications JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.
References Savall, B. M. et al.: J Med Chem. 2014 Mar 27;57(6):2429-39;

Fórmula: C₁₁H₁₉N₅·xC₂HF₃O₂

Cor e Forma: Neat

Peso molecular: 335.33

Ref: TR-J212500

JNJ 39758979

CAS: 1046447-90-8

JNJ 39758979 is a small molecule compound, which is a selective antagonist of the P2X7 receptor. This receptor is a purinergic ligand-gated ion channel sourced from human and mammalian cell lines, prominent in neurobiological and immunological tissues. The mode of action involves the inhibition of the P2X7 receptor, which plays a crucial role in inflammatory processes and cell death signaling pathways. By blocking this receptor, JNJ 39758979 reduces the release of pro-inflammatory cytokines, thus modulating neuroinflammation.

Fórmula: C₁₁H₁₉N₅

Pureza: Min. 95%

Peso molecular: 221.3 g/mol

Ref: 3D-WRB44790