CAS 104987-11-3

Tacrolimus

Descrição:

Tacrolimus, com o número CAS 104987-11-3, é um medicamento imunossupressor usado principalmente para prevenir a rejeição de órgãos em pacientes transplantados e para tratar certas condições autoimunes. É uma lactona macrolídea derivada da bactéria Streptomyces tsukubaensis. Tacrolimus funciona inibindo a ativação e proliferação de linfócitos T, principalmente através da inibição da calcineurina, uma enzima crítica na sinalização de células T. Este mecanismo ajuda a suprimir a resposta imunológica. A substância é tipicamente administrada em sua forma tópica para condições de pele como dermatite atópica ou como uma formulação oral para uso sistêmico. Tacrolimus é lipofílico, o que influencia sua absorção e distribuição no corpo. Tem uma meia-vida relativamente longa, necessitando de monitoramento cuidadoso dos níveis sanguíneos para evitar toxicidade. Os efeitos colaterais comuns incluem aumento do risco de infecções, nefrotoxicidade e neurotoxicidade. Devido aos seus potentes efeitos imunossupressores, Tacrolimus é frequentemente usado em conjunto com outros imunossupressores para aumentar a eficácia enquanto minimiza os efeitos adversos.

Fórmula: C₄₄H₆₉NO₁₂

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

Chave InChI: InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H]

Sinónimos:

• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• FR 900506
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 804.0182

Ref: IN-DA0039L0

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Cor e Forma: White To Off-White Solid

Peso molecular: 804.03

Ref: 4Z-T-391

Tacrolimus

CAS: 104987-11-3

Tacrolimus

Pureza: ≥98%

Peso molecular: 804.02g/mol

Ref: 54-BUP15701

FK-506

CAS: 104987-11-3

FK-506

Fórmula: C₄₄H₆₉NO₁₂

Pureza: By hplc: 99.91% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 804.01816g/mol

Ref: 54-BIF1003

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: >80.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 822.05

Ref: 3B-M2258

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 95%~99%

Peso molecular: 804.031

Ref: BP-BP1358

Tacrolimus

CAS: 104987-11-3

Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein

Fórmula: C₄₄H₆₉NO₁₂

Pureza: 98% - 99.94%

Cor e Forma: White Or Off-White Crystalline Powder

Peso molecular: 804.02

Ref: TM-T2144

Tacrolimus

CAS: 104987-11-3

Fórmula: C₄₄H₆₉NO₁₂

Peso molecular: 804.03

Ref: ST-EA-CP-T39000

Tacrolimus (FK506)

CAS: 104987-11-3

Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)

Fórmula: C₄₄H₆₉NO₁₂

Cor e Forma: Neat

Peso molecular: 804.02

Ref: TR-F370000

Tacrolimus - Bio-X ™

CAS: 104987-11-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 804.02 g/mol

Ref: 3D-BT164430

Tacrolimus

CAS: 104987-11-3

Antirheumatic; immunosuppressant; neuroprotective; neuroregenerative

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 804.02 g/mol

Ref: 3D-AT23293

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Produto Controlado

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Fórmula: MixtureVisitourWebsite

Cor e Forma: Mixture

Peso molecular: Mixture - Visit our Website

Ref: TR-E608165

FK-506 (Tacrolimus)

CAS: 104987-11-3

FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the rejection of transplanted organs and to treat a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. FK-506 binds to the IL-2 receptor on T-cells and inhibits their proliferation, thereby preventing activation of other immune cells. FK-506 has been shown to be effective in treating a number of diseases, including myocardial infarcts, coronary heart disease, and oral hypoglycaemic. The optimum concentration for this drug is not known, but it appears that higher concentrations are more beneficial in treating some conditions.

Fórmula: C₄₄H₆₉NO₁₂

Pureza: Min. 95%

Peso molecular: 804 g/mol

Ref: 3D-INT-3098-PI