CAS 59865-13-3

Ciclosporina A

Descrição:

Ciclosporina A é um polipeptídeo cíclico composto por 11 aminoácidos, conhecido principalmente por suas propriedades imunossupressoras. É produzido pelo fungo Tolypocladium inflatum e é amplamente utilizado em ambientes clínicos, particularmente em transplantes de órgãos e doenças autoimunes, para prevenir a rejeição de órgãos e gerenciar condições como artrite reumatoide. A substância funciona inibindo a ativação de linfócitos T, reduzindo assim a resposta imunológica. Ciclosporina A é lipofílico, o que afeta sua absorção e distribuição no corpo; geralmente é administrado por via oral ou intravenosa. Sua farmacocinética pode ser influenciada por vários fatores, incluindo a ingestão de alimentos e medicamentos concomitantes, exigindo monitoramento cuidadoso dos níveis sanguíneos para evitar toxicidade. Efeitos adversos podem incluir nefrotoxicidade, hipertensão e maior suscetibilidade a infecções. Devido às suas interações complexas e efeitos colaterais, Ciclosporina A requer gerenciamento cuidadoso e ajustes de dosagem com base na resposta individual do paciente e no contexto clínico.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Chave InChI: PMATZTZNYRCHOR-CGLBZJNRSA-N

SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Sinónimos:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: >97.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 1,202.64

Ref: 3B-C2408

Cyclosporin A, 99+%

CAS: 59865-13-3

Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99+%

Cor e Forma: White, Powder or crystals or crystalline powder

Peso molecular: 1202.61

Ref: 02-J63191

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

CAS: 59865-13-3

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

Cor e Forma: Added

Ref: 41-Y0002292

CICLOSPORIN CRS

CAS: 59865-13-3

CICLOSPORIN CRS

Cor e Forma: Added

Ref: 41-C2163000

Cyclosporine

CAS: 59865-13-3

Lactams, nesoi

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: White Powder

Peso molecular: 1201.84137

Ref: 45-1158504

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1202.6112

Ref: IN-DA00IKI7

Cyclosporine A from Beauveria Nivea

CAS: 59865-13-3

Cyclosporine A from Beauveria Nivea

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99%

Cor e Forma: White Solid

Peso molecular: 1202.61124

Ref: 54-BITP1533

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 99.00% - 99.94%

Cor e Forma: White Solid

Peso molecular: 1202.61

Ref: TM-T0945

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: ≥98%

Peso molecular: 1202.61

Ref: 54-BUP14762

Cyclosporin A (Cyclosporine)

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: White To Off-White Solid

Peso molecular: 1202.64

Ref: 4Z-PC-541

Cyclosporin A, USP grade

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: ≤ 0.7%

Cor e Forma: Colourless crystals, or white to almost white powder

Peso molecular: 1202.61

Ref: 7W-GA2331

Cyclosporin A-13C2-d4 (Cyclosporine-13C2-d4)

CAS: 59865-13-3

Fórmula: C₆₀₁₃C₂H₁₀₇D₄N₁₁O₁₂

Peso molecular: 1208.64

Ref: 4Z-PC-5441

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 97%

Cor e Forma: Solid-Powder

Peso molecular: 1202.62

Ref: 54-BI4559

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 98.5 - 101.5 % (dried basis)

Cor e Forma: Colourless crystals, or white to almost white powder

Peso molecular: 1202.61

Ref: 7W-GA6323

Cyclosporin A

Produto Controlado

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1202.61

Ref: 04-C11836300

Cyclosporin A

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: 95%~99%

Peso molecular: 1202.64

Ref: BP-BP0438

Ciclosporin

Produto Controlado

CAS: 59865-13-3

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1202.61

Ref: 86-MM0241.00

Cyclosporin A-d4 (Major)

Produto Controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₀₇D₄N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Produto Controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1202.61

Ref: TR-C988900