CAS 1057882-82-2

Acetamide, N-(4-bromo-2-methylphenyl)-2-[[(7-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]methylamino]-

Fórmula: C₂₁H₂₁BrN₂O₄

InChI: InChI=1S/C21H21BrN2O4/c1-12-8-15(22)4-6-17(12)23-19(26)11-24(3)10-14-9-20(27)28-21-13(2)18(25)7-5-16(14)21/h4-9,25H,10-11H2,1-3H3,(H,23,26)

Chave InChI: VRVRPZJTYVPJNC-UHFFFAOYSA-N

SMILES: CC1=C(C=CC(=C1)Br)NC(=O)CN(C)CC2=CC(=O)OC3=C2C=CC(=C3C)O

Sinónimos:

• Acetamide, N-(4-bromo-2-methylphenyl)-2-[[(7-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-4-yl)methyl]methylamino]-

AKR1C3-IN-14

CAS: 1057882-82-2

AKR1C3-IN-14 (compound 4) is an inhibitor of AKR1C3 enzyme, exhibiting an IC50 value of 0.122 μM. It reduces excess androgen production by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. Additionally, AKR1C3-IN-14 plays a role in the biosynthesis of prostaglandin PGF2α, influencing this pathway to regulate cell proliferation. This compound is utilized in the research of prostate cancer.

Fórmula: C₂₁H₂₁BrN₂O₄

Peso molecular: 445.31

Ref: TM-T88498