CAS 106375-28-4

ômega-conotoxina GVIA

Descrição:

ômega-conotoxina GVIA é um peptídeo derivado do veneno do caracol cone marinho, Conus geographus. É classificado como uma neurotoxina e sua função principal é a de um bloqueador seletivo dos canais de cálcio dependentes de voltagem do tipo N (VGCCs), que desempenham um papel crucial na liberação de neurotransmissores e na excitabilidade neuronal. Este composto é composto por uma sequência de aminoácidos que formam uma estrutura tridimensional característica, permitindo que se ligue especificamente aos canais de cálcio. ômega-conotoxina GVIA despertou interesse na pesquisa farmacológica devido às suas potenciais aplicações no manejo da dor e em distúrbios neurológicos, pois pode modular a transmissão sináptica. Sua especificidade para canais do tipo N torna-o uma ferramenta valiosa para estudar a sinalização do cálcio em neurônios. Além disso, a estabilidade e potência do composto contribuem para sua utilidade tanto na pesquisa básica quanto em contextos terapêuticos potenciais. Assim como muitas conotoxinas, considerações de segurança e dosagem são fundamentais devido à sua potente atividade biológica.

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

InChI: InChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)97(180)147-78(45-163)117(200)156-38-61(170)32-85(156)111(194)133-37-90(175)134-74(41-159)102(185)145-76(43-161)105(188)152-83(109(192)148-79(46-164)118(201)158-40-63(172)34-87(158)113(196)155-92(54(2)166)115(198)146-77(44-162)103(186)140-70(30-56-15-21-59(168)22-16-56)99(182)141-72(35-88(124)173)100(183)150-84)51-206-205-50-82(151-104(187)75(42-160)144-96(179)67(137-106(80)189)11-7-27-131-119(127)128)108(191)143-73(36-89(125)174)116(199)157-39-62(171)33-86(157)112(195)142-71(101(184)154-91)31-57-17-23-60(169)24-18-57/h13-24,53-54,61-87,91-92,159-172H,3-12,25-52,121-123H2,1-2H3,(H2,124,173)(H2,125,174)(H2,126,176)(H,133,194)(H,134,175)(H,135,177)(H,136,178)(H,137,189)(H,138,197)(H,139,190)(H,140,186)(H,141,182)(H,142,195)(H,143,191)(H,144,179)(H,145,185)(H,146,198)(H,147,180)(H,148,192)(H,149,181)(H,150,183)(H,151,187)(H,152,188)(H,153,193)(H,154,184)(H,155,196)(H4,127,128,131)(H4,129,130,132)/t53-,54-,61-,62-,63-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,91+,92+/m1/s1

Chave InChI: FDQZTPPHJRQRQQ-NZPQQUJLSA-N

SMILES: C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O

Sinónimos:

• w-Conotoxin GVIA, Conus geographus
• H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26)
• o-Conotoxin GVIA
• CKS(Hyp)GSSCS(Hyp)TSYNCCRSCN(Hyp)YTKRCY-NH2
• L-Tyrosinamide, L-cysteinyl-L-lysyl-L-seryl-(4R)-4-hydroxy-L-prolylglycyl-L-seryl-L-seryl-L-cysteinyl-L-seryl-(4R)-4-hydroxy-L-prolyl-L-threonyl-L-seryl-L-tyrosyl-L-asparaginyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-seryl-L-cysteinyl-L-asparaginyl-(4R)-4-hydroxy-L-prolyl-L-tyrosyl-L-threonyl-L-lysyl-L-...
• OMEGA-CONOTOXIN GVIA ISOMER
• ω-conotoxin gvia
• CKS(HYP)GSSCS(HYP)TSYNCCRSCN(HYP)TKRCY-NH2
• CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2
• ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem
• H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2 (DISULFIDE BRIDGES: 1-16, 8-19, 15-26)
• w-ConotoxinGVIA
• OMEGA-CONOTOXIN GVIA USP/EP/BP
• Omega-Conotoxin GVIA trifluoroacetate salt
• OMEGA-CONOTOXIN GVIA
• OMEGA-CONOTOXIN GVIA, CONUS GEOGRAPHUS
• H-CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2
• Disulfide bridges: 1 - 16, 8 - 19, 15 - 26
• OMEGA-CGTX GVIA

ω-Conotoxin GVIA

CAS: 106375-28-4

ω-Conotoxin GVIA from the venom of the fish-hunting cone snail Conus geographus efficiently blocks neuronal calcium channels. This presynaptic inhibition of calcium influx prevents the voltage-activated release of acetylcholine.

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Pureza: 98.1%

Cor e Forma: White Lyophilisate

Peso molecular: 3037.39

Ref: 01-4016306

ω-Conotoxin GVIA

CAS: 106375-28-4

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Pureza: 96%

Peso molecular: 3037.3479

Ref: IN-DA008RN3

ω-Conotoxin GVIA

CAS: 106375-28-4

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Peso molecular: 3037.35

Ref: 7W-GK4252

Omega-Conotoxin GVIA trifluoroacetate salt

Produto Controlado

CAS: 106375-28-4

Omega-Conotoxin GVIA is a type of toxin from the venom of the marine snail Conus geographus. It binds to the kappa-opioid receptor, which is found on neurons in the central and peripheral nervous system. This binding inhibits voltage-dependent calcium channels and leads to neuronal death. Omega-Conotoxin GVIA has been shown to inhibit diastolic pressure in rats, as well as glomerular filtration rate (GFR) and kappa-opioid receptors in mice. The inhibition of GFR may be due to its effect on Ca2+ signaling, leading to decreased activity of the Na/K ATPase pump in proximal tubules.

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Pureza: Min. 95%

Peso molecular: 3,037.36 g/mol

Ref: 3D-FC109903

omega-Conotoxin GVIA

CAS: 106375-28-4

Omega-Conotoxin GVIA is a peptide toxin that binds to the nicotinic acetylcholine receptor (nAChR) and blocks its function. It has been shown to be an inhibitor of voltage-gated potassium channels, which are responsible for regulating the electrical activity in cells. Omega-conotoxin GVIA is purified with a high degree of purity and has been shown to have no significant cross-reactivity with other nAChR subtypes. This toxin can be used as a research tool to study nAChR physiology or as an antibody to target this receptor in cell biology experiments.

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Pureza: Min. 95%

Peso molecular: 3,037.3 g/mol

Ref: 3D-PCN-4161-V

ω-Conotoxin GVIA

CAS: 106375-28-4

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.

Fórmula: C₁₂₀H₁₈₂N₃₈O₄₃S₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3037

Ref: TM-TP2062