CAS 1140909-48-3

cabozantinib (S)-malato

Descrição:

cabozantinib (S)-malato é um inibidor de moléculas pequenas usado principalmente na terapia do câncer, particularmente para tratar carcinoma de células renais avançado e carcinoma hepatocelular. Funciona como um inibidor de tirosina quinase, visando múltiplos caminhos envolvidos no crescimento tumoral e na metástase, incluindo MET, VEGFR e AXL. A forma (S)-malato indica que o composto é um sal derivado do ácido málico, o que melhora sua solubilidade e biodisponibilidade. O cabozantinibe exibe uma estrutura complexa que inclui um núcleo central com vários grupos funcionais, contribuindo para sua atividade farmacológica. O composto é tipicamente administrado por via oral e possui um perfil farmacocinético específico, incluindo características de absorção, distribuição, metabolismo e excreção que são cruciais para sua eficácia terapêutica. Os efeitos colaterais podem incluir distúrbios gastrointestinais, fadiga e hipertensão, refletindo seu mecanismo de ação nas vias vasculares e celulares. No geral, cabozantinib (S)-malato representa um avanço significativo nas terapias direcionadas ao câncer, oferecendo uma abordagem multifacetada para inibir a progressão tumoral.

Fórmula: C₃₂H₃₀FN₃O₁₀

InChI: InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

Chave InChI: InChIKey=HFCFMRYTXDINDK-WNQIDUERSA-N

SMILES: C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4.[C@H](CC(O)=O)(C(O)=O)O

Sinónimos:

• (2S)-2-Hydroxybutanedioic acid compd.with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide(1:1)
• (2S)-2-hydroxybutanedioic acid
• Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
• Cabozantinib L-(-)-Apple Acid
• Cabozantinib L-Malate
• Cabozantinib Malate
• Cometriq
• N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
• N1-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N1'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• Xl 184
• Cabozantinib S-malate
• Cabozantinib S-malate
• Cabozantinib L-Malate Salt
• N-[4-[(6,7-DiMethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide (2S)-
• Cabozantinib (S)-Malate(XL-184)
• Cabozantinib Malate (XL184)
• XL184(S)-malate
• Cabozantinib malate, >=99%
• Cabozantinib (S)-malate (2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
• Smalate
• XL184(Cabozantinib malate)
• XL-184 (Malate)

Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

CAS: 1140909-48-3

Fórmula: C₃₂H₃₀FN₃O₁₀

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 635.5931

Ref: IN-DA000AJ8

Cabozantinib (S)-Malate

CAS: 1140909-48-3

Fórmula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 501.51 134.09

Ref: 4Z-C-284013

Cabozantinib S-malate

CAS: 1140909-48-3

Cabozantinib S-malate

Fórmula: C₃₂H₃₀FN₃O₁₀

Pureza: ≥98%

Cor e Forma: Solid

Peso molecular: 635.59

Ref: 54-BUP15407

Cabozantinib (S)-Malate

CAS: 1140909-48-3

Cor e Forma: Neat

Ref: 86-MM3947.00

Cabozantinib S-malate

CAS: 1140909-48-3

Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK inhibitor with potential antineoplastic activity.

Fórmula: C₃₂H₃₀FN₃O₁₀

Pureza: 98% - >99.99%

Cor e Forma: Solid

Peso molecular: 635.59

Ref: TM-T1797

Cabozantinib S-malate

CAS: 1140909-48-3

N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate

Fórmula: C₃₂H₃₀FN₃O₁₀

Pureza: 99+%

Peso molecular: 635.59

Ref: IN-DG434994

Cabozantinib malate

CAS: 1140909-48-3

Fórmula: C₃₂H₃₀FN₃O₁₀

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 635.59

Ref: 7W-GP4726

Cabozantinib (Phenylene-d4) L-Malate Salt

Produto Controlado

CAS: 1140909-48-3

Applications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),

Fórmula: C₂₈D₄H₂₀FN₃O₅·C₄H₆O₅

Cor e Forma: Neat

Peso molecular: 639.62

Ref: TR-C051502

Cabozantinib L-Malate Salt

Produto Controlado

CAS: 1140909-48-3

Applications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),

Fórmula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Cor e Forma: Neat

Peso molecular: 635.59

Ref: TR-C051500

Cabozantinib malate

CAS: 1140909-48-3

Inhibits MET, VEGFR1, VEGFR2; VEGFR3 receptor tyrosine kinases; antineoplastic

Fórmula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 635.6 g/mol

Ref: 3D-FC64967

Cabozantinib S-malate

CAS: 1140909-48-3

Ref: BE-RMCC005012

Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

CAS: 1140909-48-3

Pureza: 98%

Peso molecular: 635.6010132

Ref: 10-F861544

Cabozantinib S-Malate

CAS: 1140909-48-3

Fórmula: C₂₈H₂₄FN₃O₅C₄H₆O₅

Peso molecular: 501.5 : 134.1

Ref: ST-EA-CP-C46019