CAS 114870-03-0

Fondaparinux

Descrição:

Fondaparinux é um anticoagulante sintético que pertence à classe de medicamentos conhecidos como inibidores do fator Xa. É utilizado principalmente para a prevenção e tratamento da tromboembolismo venoso, incluindo trombose venosa profunda e embolia pulmonar. Fondaparinux atua inibindo seletivamente o fator Xa, um componente essencial na cascata de coagulação, prevenindo assim a formação de coágulos sanguíneos. A substância é caracterizada por sua alta biodisponibilidade quando administrada por via subcutânea e uma longa meia-vida, permitindo uma dosagem uma vez ao dia. Fondaparinux é solúvel em água e possui baixo peso molecular, o que contribui para suas propriedades farmacocinéticas. Não requer monitoramento rotineiro dos níveis de anticoagulação, tornando-se uma opção conveniente para os pacientes. Efeitos colaterais comuns podem incluir complicações hemorrágicas, mas geralmente é bem tolerado. Devido ao seu mecanismo de ação específico e perfil de segurança favorável, Fondaparinux é uma opção terapêutica valiosa no manejo de distúrbios tromboembólicos.

Fórmula: C₃₁H₅₃N₃O₄₉S₈·10Na

InChI: InChI=1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1

Chave InChI: InChIKey=XNHJPDRIKNIMPQ-JASSWCPGSA-N

SMILES: O([C@H]1[C@H](OS(=O)(=O)O)[C@@H](NS(=O)(=O)O)[C@@H](O[C@@H]2[C@H](C(O)=O)O[C@@H](O[C@@H]3[C@@H](COS(=O)(=O)O)O[C@H](OC)[C@H](NS(=O)(=O)O)[C@H]3O)[C@H](OS(=O)(=O)O)[C@H]2O)O[C@@H]1COS(=O)(=O)O)[C@@H]4O[C@H](C(O)=O)[C@@H](O[C@@H]5[C@H](NS(=O)(=O)O)[C@@H](O)[C@H](O)[C@@H](COS(=O)(=O)O)O5)[C@H](O)[C@H]4O.[Na]

Sinónimos:

• IC 851589
• SR 90107A
• α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), sodium salt (1:10)
• Fondaparinux sodium
• α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), decasodium salt

Fondaparinux Sodium System Suitability Mixture B Solution

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Fórmula: C₃₁H₄₃N₃O₄₉S₈Na₁₀(majorcomponent)

Cor e Forma: Colorless Liquid

Peso molecular: 1726.77078

Ref: 45-1282742

Fondaparinux Sodium Identification

CAS: 114870-03-0

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Cor e Forma: White Off-White Powder

Peso molecular: 1726.77078

Ref: 45-1282718

Fondaparinux Sodium for Assay

CAS: 114870-03-0

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Fórmula: C₃₁H₄₃N₃O₄₉S₈Na₁₀

Cor e Forma: Clear Colorless Liquid

Peso molecular: 1726.77078

Ref: 45-1282707

Fondaparinux Sodium System Suitability Mixture A Solution

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Fórmula: C₃₁H₄₃N₃O₄₉S₈Na₁₀(majorcomponent)

Cor e Forma: Liquid

Peso molecular: 1726.77078

Ref: 45-1282731

Fondaparinux Sodium Salt

CAS: 114870-03-0

Fórmula: C₃₁H₄₃N₃O₄₉S₈·10Na

Cor e Forma: White To Off-White Solid

Peso molecular: 1498.14 10*22.99

Ref: 4Z-F-711

Fondaparinux sodium salt

CAS: 114870-03-0

Fórmula: C₃₁H₄₃N₃O₄₉S₈·10Na

Peso molecular: 1728.08

Ref: 7W-GX8097

Fondaparinux Sodium Impurity 14

CAS: 114870-03-0

Fórmula: C₃₁H₄₂N₃NaO₅₂S₉·11Na

Cor e Forma: White To Off-White Solid

Peso molecular: 1600.18 11*22.99

Ref: 4Z-F-7115

Fondaparinux sodium

CAS: 114870-03-0

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1728.0815

Ref: IN-DA000FCU

Fondaparinux Sodium

Produto Controlado

CAS: 114870-03-0

Applications Synthetic pentasaccharide corresponding to the anti-thrombin binding site of heparin. Anti-thrombotic.
References Herbert, J.M., et al.: Cardiovasc. Drug Rev., 15, 1 (1997), Turpie, A.G.G., et al.: Expert Opin. Drug Saf., 4, 707 (2005),

Fórmula: C₃₁H₄₃N₃O₄₉S₈·10Na

Cor e Forma: Neat

Peso molecular: 1728.08

Ref: TR-F683500

Fondaparinux sodium

CAS: 114870-03-0

Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Pureza: 98% - >99.99%

Cor e Forma: Solid

Peso molecular: 1728.082

Ref: TM-T4076

Fondaparinux sodium

CAS: 114870-03-0

(2S,3S,4R,5R,6R)-6-(((2R,3R,4R,5R,6R)-6-(((2R,3S,4S,5R,6R)-2-Carboxy-4-hydroxy-6-(((2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfoamino)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfooxy)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfoamino)-4-(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfoamino)-6-((sulfooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-carboxylic acid, decasodium salt

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Pureza: 98%

Peso molecular: 1728.08

Ref: IN-DG168756

Fondaparinux sodium

CAS: 114870-03-0

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Peso molecular: 1728.1

Ref: BE-RMCF171001

FONDAPARINUX SODIUM

CAS: 114870-03-0

Pureza: 98%

Peso molecular: 1728.030029

Ref: 10-F799841

Fondaparinux-dx Sodium

Produto Controlado

CAS: 114870-03-0

Fórmula: C₃₁H₃₅D₉N₃Na₁₀O₄₉S₈

Cor e Forma: Neat

Ref: TR-F683503

Fondaparinux Sodium System Suitability Mixture B

CAS: 114870-03-0

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Fórmula: C₃₁H₄₃N₃O₄₉S₈Na₁₀

Cor e Forma: White Powder

Peso molecular: 1726.77078

Ref: 45-1282730

Fondaparinux sodium

CAS: 114870-03-0

Fondaparinux sodium is an anticoagulant, which is a synthetic pentasaccharide based on the antithrombin-binding sequence of heparin. As a meticulously engineered compound, it is derived by chemical synthesis. Its mode of action involves the selective inhibition of factor Xa, a critical enzyme in the coagulation cascade. By binding specifically to antithrombin III, it enhances the inactivation of factor Xa, thereby interrupting the pathway that leads to thrombin formation and ultimately preventing fibrin clot formation.

Fórmula: C₃₁H₄₃N₃Na₁₀O₄₉S₈

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 1,728.09 g/mol

Ref: 3D-OF04094