CAS 1211877-36-9

Fórmula: C26H41N3O5

InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

Chave InChI: TZYWCYJVHRLUCT-ZRBLBEILSA-N

SMILES: CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

(R)-MG-132

CAS: 1211877-36-9

(R)-MG-132

Fórmula: C₂₆H₄₁N₃O₅

Pureza: ≥98%

Peso molecular: 475.62

Ref: 54-BUP12924

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

CAS: 1211877-36-9

Fórmula: C₂₆H₄₁N₃O₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 475.6208

Ref: IN-DA009BMJ

(R)-MG-132

CAS: 1211877-36-9

Benzyl ((S)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)((S)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

Fórmula: C₂₆H₄₁N₃O₅

Pureza: 98% (NMR）

Peso molecular: 475.62

Ref: IN-DG758089

(R)-MG-132

CAS: 1211877-36-9

(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

Fórmula: C₂₇H₄₃N₃O₅

Pureza: 99.90%

Cor e Forma: Solid

Peso molecular: 489.6474

Ref: TM-T12628

(R)-MG-132

Produto Controlado

CAS: 1211877-36-9

Fórmula: C₂₆H₄₁N₃O₅

Cor e Forma: Neat

Peso molecular: 475.621

Ref: TR-M340975

(R)-MG 132

CAS: 1211877-36-9

Ischemia reperfusion injury is a major cause of irreversible brain damage. The enzyme GTPase-activating protein (GAP) has been shown to be involved in the regulation of cell death and may represent a potential therapeutic target for ischemia reperfusion injury. MG132 is an inhibitor of GAP and can protect against brain damage in wild-type mice subjected to cerebral ischemia reperfusion injury. MG132 blocks protein synthesis, leading to apoptotic cell death in cancer cells, while it induces apoptotic cell death in cancer cells. MG132 also inhibits proteasome activity and leads to acute ischemic brain damage in wild-type mice.

Fórmula: C₂₆H₄₁N₃O₅

Pureza: Min. 95%

Peso molecular: 475.63 g/mol

Ref: 3D-LYB87736