CAS 121204-87-3

(ala,1,3,11,15)-endotelina-1

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

InChI: InChI=1/C109H163N25O32S/c1-16-56(9)86(113)104(159)134-88(57(10)17-2)106(161)129-78(43-64-47-115-69-28-22-21-27-67(64)69)108(163)166-109(164)79(46-84(141)142)128-97(152)72(39-53(3)4)124-99(154)75(44-65-48-114-52-116-65)122-90(145)59(12)118-96(151)73(41-62-25-19-18-20-26-62)125-98(153)74(42-63-30-32-66(138)33-31-63)126-105(160)87(55(7)8)133-92(147)61(14)117-94(149)71(121-95(150)70(29-23-24-37-110)120-100(155)76(45-83(139)140)123-93(148)68(112)36-38-167-15)34-35-85(143)165-107(162)77(40-54(5)6)127-102(157)82(51-137)132-103(158)81(50-136)131-91(146)60(13)119-101(156)80(49-135)130-89(144)58(11)111/h18-22,25-28,30-33,47-48,52-61,65,68,70-82,86-88,115,135-138H,16-17,23-24,29,34-46,49-51,110-113H2,1-15H3,(H,117,149)(H,118,151)(H,119,156)(H,120,155)(H,121,150)(H,122,145)(H,123,148)(H,124,154)(H,125,153)(H,126,160)(H,127,157)(H,128,152)(H,129,161)(H,130,144)(H,131,146)(H,132,158)(H,133,147)(H,134,159)(H,139,140)(H,141,142)/t56-,57-,58-,59-,60-,61-,65?,68-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-/m0/s1

Chave InChI: KIYSPBOGUDIMPC-SCGUGKIPSA-N

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(=O)[C@H](CC(=O)O)N=C([C@H](CC(C)C)N=C([C@H](CC1C=NC=N1)N=C([C@H](C)N=C([C@H](Cc1ccccc1)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](C)N=C([C@H](CCC(=O)OC(=O)[C@H](CC(C)C)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C([C@H](CO)N=C([C@H](C)N)O)O)O)O)O)N=C([C@H](CCCCN)N=C([C@H](CC(=O)O)N=C([C@H](CCSC)N)O)O)O)O)O)O)O)O)O)O)O)O)O)N

Sinónimos:

• (Ala131115)-Endothelin-1
• H-Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH

(Ala¹·³·¹¹·¹⁵)-Endothelin-1

CAS: 121204-87-3

4 Ala ET-1, linear analog of ET-1 is a selective agonist for ET-B receptors.

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

Pureza: 95.5%

Cor e Forma: White Powder

Peso molecular: 2367.71

Ref: 01-4030582

[Ala1,3,11,15]-Endothelin 1

CAS: 121204-87-3

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

Pureza: ≥ 95.0%

Cor e Forma: White solid

Peso molecular: 2367.67

Ref: 7W-GK1126

[Ala1,3,11,15]-Endothelin

CAS: 121204-87-3

Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 2368

Ref: TM-TP2099

(Ala131115)-Endothelin-1 trifluoroacetate salt H-Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH trifluoroacetate salt

CAS: 121204-87-3

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

Pureza: 95%

Peso molecular: 2367.6738

Ref: IN-DA01EAS8

(Ala1·3·11·15)-Endothelin-1 trifluoroacetate salt

CAS: 121204-87-3

(Ala1·3·11·15)-Endothelin-1 trifluoroacetate salt H-Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu) is a phorbol ester, which is an analog of endothelin. It has been shown to inhibit the production of proinflammatory cytokines and chemokines in vitro and in vivo. This compound also inhibits the migration and proliferation of vascular endothelial cells, which may be due to its ability to suppress Ca2+ concentration. (Ala1·3·11·15)-Endothelin -1 trifluoroacetate salt H-) can also be used as a fluorescent marker for immunohistochemical studies on tissues such as vessels and gastrointestinal tissues. The localization of this drug can be observed by microscopy techniques such as

Fórmula: C₁₀₉H₁₆₃N₂₅O₃₂S

Pureza: Min. 95%

Peso molecular: 2,367.68 g/mol

Ref: 3D-FA108867