CAS 123172-94-1

Heptakis-(2,3-di-O-acetil-6-O-terc.-butil-dimetilsilil)-beta-ciclodextrina

Descrição:

Heptakis-(2,3-di-O-acetil-6-O-terc.-butil-dimetilsilil)-beta-ciclodextrina é uma forma modificada de beta-ciclodextrina, um oligosacarídeo cíclico composto por sete unidades de glicose. Este composto apresenta múltiplos grupos funcionais que aumentam sua solubilidade e estabilidade, tornando-o útil em várias aplicações, particularmente na entrega e formulação de medicamentos. Os grupos acetila proporcionam maior lipofilicidade, enquanto o grupo tert-butyldimethylsilyl melhora a resistência do composto à hidrólise e sua compatibilidade com solventes orgânicos. Essas modificações permitem uma melhor encapsulação de moléculas hidrofóbicas, facilitando a formação de complexos de inclusão. O composto exibe propriedades como melhor biodisponibilidade de medicamentos, perfis de liberação controlada e maior estabilidade de compostos sensíveis. Sua estrutura única permite formar complexos hospedeiro-convidado, que são essenciais em aplicações farmacêuticas. Além disso, a presença de grupos silyl e acetila pode influenciar a interação do composto com sistemas biológicos, tornando-o um tema de interesse em química medicinal e ciência dos materiais. No geral, esta beta-ciclodextrina modificada serve como uma ferramenta versátil para melhorar a entrega e eficácia de vários agentes terapêuticos.

Fórmula: C₁₁₂H₁₉₆O₄₉Si₇

InChI: InChI=1/C112H196O49Si7/c1-57(113)134-85-78-71(50-127-162(36,37)106(15,16)17)148-99(92(85)141-64(8)120)156-79-72(51-128-163(38,39)107(18,19)20)150-101(94(143-66(10)122)86(79)135-58(2)114)158-81-74(53-130-165(42,43)109(24,25)26)152-103(96(145-68(12)124)88(81)137-60(4)116)160-83-76(55-132-167(46,47)111(30,31)32)154-105(98(147-70(14)126)90(83)139-62(6)118)161-84-77(56-133-168(48,49)112(33,34)35)153-104(97(146-69(13)125)91(84)140-63(7)119)159-82-75(54-131-166(44,45)110(27,28)29)151-102(95(144-67(11)123)89(82)138-61(5)117)157-80-73(52-129-164(40,41)108(21,22)23)149-100(155-78)93(142-65(9)121)87(80)136-59(3)115/h71-105H,50-56H2,1-49H3/t71?,72?,73?,74?,75?,76?,77?,78-,79-,80-,81-,82-,83-,84-,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99-,100-,101-,102-,103-,104-,105+/m1/s1

Chave InChI: BDKOXGFFUPKZPF-AOFVQSMMSA-N

SMILES: CC(=O)O[C@H]1[C@H]2[C@H](O[C@@H]([C@@H]1OC(=O)C)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3OC(=O)C)OC(=O)C)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4OC(=O)C)OC(=O)C)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5OC(=O)C)OC(=O)C)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6OC(=O)C)OC(=O)C)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7OC(=O)C)OC(=O)C)O[C@@H]8[C@H](O[C@H](O2)[C@@H]([C@H]8OC(=O)C)OC(=O)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C

Sinónimos:

• Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin Tetradecaacetate
• 6A,6B,6C,6D,6E,6F,6G-Heptakis-O-[(1,1-diMethylethyl)diMethylsilyl]-β-cyclodextrin 2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3G-Tetradecaacetate
• Heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)cyclomaltoheptaose
• Heptakis-(2,3-di-O-acetyl-6-O-tert.-Butyldimethylsilyl)-beta-Cyclodextrin
• Hydrodex β-TBDAc

Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate

CAS: 123172-94-1

Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate is a chemically modified cyclodextrin with effective solubilizing properties. It is widely used in compound formulations to enhance solubility and bioavailability. Additionally, Heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin tetradecaacetate aids in improving the release characteristics of compounds.

Fórmula: C₁₁₂H₁₉₆O₄₉Si₇

Peso molecular: 2523.32

Ref: TM-TSH-00168

Heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)cyclomaltoheptaose

CAS: 123172-94-1

This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.

Fórmula: C₁₁₂H₁₉₆O₄₉Si₇

Pureza: Min. 95%

Peso molecular: 2,523.32 g/mol

Ref: 3D-OH46499

Heptakis(6-O-tert-butyldimethylsilyl)-Beta-cyclodextrin Tetradecaacetate

Produto Controlado

CAS: 123172-94-1

Applications Compound used as stationary phase in HPLC columns to separate E and Z isomers
References Kasai, H., et al.: Chem. Pharm. Bull., 52, 311 (2004),

Fórmula: C₁₁₂H₁₉₆O₄₉Si₇

Cor e Forma: Neat

Peso molecular: 2523.32

Ref: TR-H281090