CAS 125971-94-0

1,1-Dimetiletil (4R,6R)-6-(cianometil)-2,2-dimetil-1,3-dioxano-4-acetato

Descrição:

1,1-Dimetiletil (4R,6R)-6-(cianometil)-2,2-dimetil-1,3-dioxano-4-acetato, com o número CAS 125971-94-0, é um composto químico caracterizado por sua estrutura complexa, que inclui um anel de dioxano e vários grupos funcionais, como um grupo cianometila e um moiety de acetato. Este composto provavelmente exibirá propriedades típicas de derivados de dioxano, incluindo potencial solubilidade em solventes orgânicos e estabilidade sob certas condições. A presença do grupo cianometila sugere reatividade potencial, particularmente em reações de adição nucleofílica. A estereoquímica indicada pela configuração (4R,6R) pode influenciar sua atividade biológica e interações com outras moléculas. Assim como muitos compostos orgânicos, suas propriedades físicas, como ponto de ebulição, ponto de fusão e densidade, dependeriam das interações moleculares específicas e da presença de grupos funcionais. Dados de segurança e precauções de manuseio devem ser consultados, uma vez que compostos com funcionalidades de cianeto podem apresentar riscos de toxicidade. No geral, este composto pode ter aplicações em síntese orgânica ou como um intermediário no desenvolvimento farmacêutico.

Fórmula: C₁₄H₂₃NO₄

InChI: InChI=1/C14H23NO4/c1-13(2,3)19-12(16)9-11-8-10(6-7-15)17-14(4,5)18-11/h10-11H,6,8-9H2,1-5H3/t10-,11-/m1/s1

Chave InChI: InChIKey=DPNRMEJBKMQHMC-GHMZBOCLSA-N

SMILES: C(C(OC(C)(C)C)=O)[C@@H]1OC(C)(C)O[C@H](CC#N)C1

Sinónimos:

• ((4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester
• (4R,3R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
• (4R,6R)-t-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate (ATS-8)
• (4R,Cis)-1,1-dimethylethyl-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dlmethyl-1,3-dioxane-4-acetate
• (6R-Cyanomethyl-2,2-dimethyl-[1,3]dioxan-4R-yl)acetic acid tert-butyl ester
• 1,1-Dimethylethyl (4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R-cis)-
• ATS-8(for Atorvastatin)
• Ast-8
• Atorvastatin Calcium Intermediate ATS-8
• AtorvastatinCalcium(ATS-8)
• Ats-8
• Tert-Butyl (4R,3R)-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
• Tert-Butyl 2-((4R,6R)-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl) acetate
• tert-Butyl(3R,5R)-6-cyano-3,5-O-iso-propylidene-3,5-dihydroxyhexanoate
• tert-butyl [(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate
• (4R,CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE(ATS-8)
• Intermediateofatorvastatinecalcium(CAS#134523-03-8)
• (4R,6R)-Tert-Butyl-6-Cyanometh
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-1,1-dimethylethylester
• Ats-8:(4R,Cis)-1,1-Dimethylethyl-Cyanomethyl-2,2-Dimethyl
• ATS-8:(4R-CIS)-T-ETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,2-DIMETHYL-1,2-DIONMANO 1 ACETATE
• (4R-Cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dio-cxane-4-acetate
• (4R,6R)-t-Butyl-6-AMINOMETHYL-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-t-butyl-6-cyanomethyl02,2-dimethyl-1,3-dioxane-4-acetate
• ATS 8 (4R,CIS)-1,1-DIMETHYLETHY-L-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE
• TERT-BUTYL[(4R,6R)-6-CYANOMETHYL-1,3-DIOXAN-4-YL]ACETATE
• (4R-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dloxane-4-acetate

tert-Butyl (4R,6R)-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

CAS: 125971-94-0

Fórmula: C₁₄H₂₃NO₄

Pureza: >98.0%(GC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 269.34

Ref: 3B-B3642

1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

CAS: 125971-94-0

Fórmula: C₁₄H₂₃NO₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 269.3367

Ref: IN-DA000QLY

Tert-Butyl 2-((4R,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

CAS: 125971-94-0

Tert-Butyl 2-((4R,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

Fórmula: C₁₄H₂₃NO₄

Pureza: >99%

Peso molecular: 269.34

Ref: 54-OR1015132

Atorvastatin Impurity 21

CAS: 125971-94-0

Fórmula: C₁₄H₂₃NO₄

Cor e Forma: White To Off-White Solid

Peso molecular: 269.34

Ref: 4Z-A-1257

1,1-Dimethylethyl 2-[(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

CAS: 125971-94-0

Cor e Forma: Neat

Ref: 86-MM0400.37

tert-butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

CAS: 125971-94-0

tert-Butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Fórmula: C₁₄H₂₃NO₄

Pureza: 95%

Peso molecular: 269.34

Ref: IN-DG5737

(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester

Produto Controlado

CAS: 125971-94-0

Applications (4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

Fórmula: C₁₄H₂₃NO₄

Cor e Forma: Neat

Peso molecular: 269.34

Ref: TR-C982020

Atorvastatin Acetonide t-Butyl Ester Side Chain (4R,6R)-Isomer

CAS: 125971-94-0

Fórmula: C₁₄H₂₃NO₄

Peso molecular: 269.34

Ref: ST-EA-CP-A32061