CAS 128625-52-5

PyBOP

Descrição:

PyBOP, ou benzotriazol-1-il-óxido-tris(dimetilamino)fosfonio hexafluorofosfato, é um reagente de acoplamento comumente utilizado na síntese de peptídeos. Facilita a formação de ligações peptídicas ao ativar ácidos carboxílicos, tornando-os mais reativos em relação às aminas. PyBOP é caracterizado por sua alta eficiência e condições de reação suaves, que ajudam a minimizar reações secundárias e proteger grupos funcionais sensíveis. É tipicamente utilizado na síntese de peptídeos em fase sólida e reações em fase de solução. O reagente é conhecido por sua estabilidade e facilidade de manuseio, sendo frequentemente preferido em relação a outros agentes de acoplamento devido à sua capacidade de fornecer altos rendimentos dos produtos peptídicos desejados. Além disso, PyBOP é solúvel em solventes orgânicos comuns, o que aumenta sua versatilidade em vários protocolos sintéticos. No entanto, é importante manusear PyBOP com cuidado, pois pode ser perigoso, e medidas de segurança adequadas devem ser tomadas durante seu uso. No geral, PyBOP é uma ferramenta valiosa no campo da química orgânica e medicinal, particularmente na síntese de peptídeos complexos.

Fórmula: C₁₈H₂₈N₆OP·F₆P

InChI: InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1

Chave InChI: InChIKey=VIAFLMPQBHAMLI-UHFFFAOYSA-N

SMILES: [P+](ON1C=2C(N=N1)=CC=CC2)(N3CCCC3)(N4CCCC4)N5CCCC5.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]

Sinónimos:

• (1-Hydroxy-1H-benzotriazolato-O)tri-1-pyrrolidinylphosphorus(1+) hexafluorophosphate(1-)
• 1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate
• 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate
• 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
• Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
• Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
• Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
• Phosphorus(1+), [1-(hydroxy-κO)-1H-benzotriazolato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
• PyBOP
• Pyrrolidine, phosphorus complex

1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]

CAS: 128625-52-5

Fórmula: C₁₈H₂₈F₆N₆OP₂

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 520.40

Ref: 3B-B1774

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

CAS: 128625-52-5

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent. This Thermo Scientific C

Fórmula: C₁₈H₂₈N₆OP

Pureza: 98%

Cor e Forma: White to pale cream, Crystals or powder or crystalline powder

Peso molecular: 375.44

Ref: 02-B25251

1H-Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

Fórmula: C₁₈H₂₈F₆N₆OP₂

Pureza: 98.0%

Cor e Forma: Solid, Powder or Crystalline Powder or Solid or Chunks

Peso molecular: 520.401

Ref: 10-F009017

PyBOP

CAS: 128625-52-5

A trademark of Merck KGaA, Darmstadt, Germany PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.

Fórmula: C₁₈H₂₈N₆OP·PF₆

Cor e Forma: White

Peso molecular: 520.4

Ref: 01-4031604

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

Fórmula: C₁₈H₂₈F₆N₆OP₂

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 520.3925

Ref: IN-DA000Y92

Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate

CAS: 128625-52-5

Fórmula: C₁₈H₂₈N₆OP·PF₆

Pureza: ≥ 97.5%

Cor e Forma: White to off-white or slightly yellow crystalline powder

Peso molecular: 520.40

Ref: 7W-GE4655

[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

CAS: 128625-52-5

[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

Fórmula: C₁₈H₂₈N₆OP·PF₆

Pureza: ≥95%

Cor e Forma: white crystalline solid

Peso molecular: 520.39g/mol

Ref: 54-PC1208

Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate

Produto Controlado

CAS: 128625-52-5

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.

Fórmula: C₁₈H₂₈N₆OP·F₆P

Cor e Forma: Neat

Peso molecular: 520.39

Ref: TR-B207500

PyBOP

CAS: 128625-52-5

PyBOP is an acyclic nucleoside phosphonate that is structurally similar to cyclic peptides and coumarin derivatives. It has been shown to be active against infectious diseases such as malaria and hepatitis C, as well as metabolic disorders such as obesity. PyBOP also has a number of physiological effects, including thermal expansion and immunomodulation. PyBOP binds to the 3'-hydroxyl group of RNA by hydrogen bonding interactions in vivo and inhibits rRNA synthesis, leading to the inhibition of protein synthesis. This drug also disrupts the disulfide bond between cysteine residues in proteins, which may lead to autoimmune diseases. PyBOP is water-soluble and highly soluble in organic solvents, but not soluble in water or polar solvents such as DMSO or acetone. br>br> The thermal expansion coefficient for PyBOP is about 10^6 K^-1mol^

Fórmula: C₁₈H₂₈N₆OP₂F₆

Pureza: Min. 95%

Peso molecular: 520.39 g/mol

Ref: 3D-KPC-1068-PI

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

CAS: 128625-52-5

PyBOP is a phosphonium salt used as a coupling reagent for peptide synthesis. PyBOP is very efficient: high yields, low epimerisation and high conversion rates can be achieved. PyBOP generates an activated HOBt ester in situ, in the presence of a base such as triethylamine or Hünig’s base. PyBOP is the pyrrolidino derivative of the phosphonium coupling reagent BOP, which is equally efficient, but generates the extremely toxic and carcinogenic HMPA as a by-product in situ. PyBOP is generally preferred over BOP because it gives comparable performances but generates a less toxic by-product.

Fórmula: C₁₈H₂₈N₆OP·PF₆

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 520.39 g/mol

Ref: 3D-FP15550