CAS 128625-52-5
:PyBOP
Descrição:
PyBOP, ou benzotriazol-1-il-óxido-tris(dimetilamino)fosfonio hexafluorofosfato, é um reagente de acoplamento comumente utilizado na síntese de peptídeos. Facilita a formação de ligações peptídicas ao ativar ácidos carboxílicos, tornando-os mais reativos em relação às aminas. PyBOP é caracterizado por sua alta eficiência e condições de reação suaves, que ajudam a minimizar reações secundárias e proteger grupos funcionais sensíveis. É tipicamente utilizado na síntese de peptídeos em fase sólida e reações em fase de solução. O reagente é conhecido por sua estabilidade e facilidade de manuseio, sendo frequentemente preferido em relação a outros agentes de acoplamento devido à sua capacidade de fornecer altos rendimentos dos produtos peptídicos desejados. Além disso, PyBOP é solúvel em solventes orgânicos comuns, o que aumenta sua versatilidade em vários protocolos sintéticos. No entanto, é importante manusear PyBOP com cuidado, pois pode ser perigoso, e medidas de segurança adequadas devem ser tomadas durante seu uso. No geral, PyBOP é uma ferramenta valiosa no campo da química orgânica e medicinal, particularmente na síntese de peptídeos complexos.
Fórmula:C18H28N6OP·F6P
InChI:InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
Chave InChI:InChIKey=VIAFLMPQBHAMLI-UHFFFAOYSA-N
SMILES:[P+](ON1C=2C(N=N1)=CC=CC2)(N3CCCC3)(N4CCCC4)N5CCCC5.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]
Sinónimos:- (1-Hydroxy-1H-benzotriazolato-O)tri-1-pyrrolidinylphosphorus(1+) hexafluorophosphate(1-)
- 1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate
- 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate
- 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
- Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
- Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
- Phosphorus(1+), [1-(hydroxy-κO)-1H-benzotriazolato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
- PyBOP
- Pyrrolidine, phosphorus complex
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Foram encontrados 13 produtos.
1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
CAS:Fórmula:C18H28F6N6OP2Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:520.40Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)
CAS:Fórmula:C18H28F6N6OP2Peso molecular:520.401H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%
CAS:1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent. This Thermo Scientific CFórmula:C18H28N6OPPureza:98%Cor e Forma:White to pale cream, Crystals or powder or crystalline powderPeso molecular:375.441H-Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
CAS:Fórmula:C18H28F6N6OP2Pureza:98.0%Cor e Forma:SolidPeso molecular:520.401Benzotriazol-1-yloxytripyrrolidino phosphonium hexafluorophosphate, min. 99% [CalBOP]
CAS:Fórmula:C18H28F6N6OP2Pureza:min. 99%Cor e Forma:WhitePeso molecular:520.39PyBOP
CAS:A trademark of Merck KGaA, Darmstadt, Germany PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.Fórmula:C18H28N6OP·PF6Cor e Forma:WhitePeso molecular:520.4(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
CAS:Fórmula:C18H28F6N6OP2Pureza:98%Cor e Forma:SolidPeso molecular:520.3925[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate
CAS:[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphateFórmula:C18H28N6OP·PF6Pureza:≥95%Cor e Forma:SolidPeso molecular:520.39246Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
CAS:Fórmula:C18H28N6OP·PF6Pureza:≥ 97.5%Cor e Forma:White to off-white or slightly yellow crystalline powderPeso molecular:520.40Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate
CAS:Produto ControladoApplications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.
Fórmula:C18H28N6OP·F6PCor e Forma:NeatPeso molecular:520.39PyBOP
CAS:PyBOP is an acyclic nucleoside phosphonate that is structurally similar to cyclic peptides and coumarin derivatives. It has been shown to be active against infectious diseases such as malaria and hepatitis C, as well as metabolic disorders such as obesity. PyBOP also has a number of physiological effects, including thermal expansion and immunomodulation. PyBOP binds to the 3'-hydroxyl group of RNA by hydrogen bonding interactions in vivo and inhibits rRNA synthesis, leading to the inhibition of protein synthesis. This drug also disrupts the disulfide bond between cysteine residues in proteins, which may lead to autoimmune diseases. PyBOP is water-soluble and highly soluble in organic solvents, but not soluble in water or polar solvents such as DMSO or acetone. br>br> The thermal expansion coefficient for PyBOP is about 10^6 K^-1mol^
Fórmula:C18H28N6OP2F6Pureza:Min. 95%Peso molecular:520.39 g/mol(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
CAS:PyBOP is a phosphonium salt used as a coupling reagent for peptide synthesis. PyBOP is very efficient: high yields, low epimerisation and high conversion rates can be achieved. PyBOP generates an activated HOBt ester in situ, in the presence of a base such as triethylamine or Hünig’s base. PyBOP is the pyrrolidino derivative of the phosphonium coupling reagent BOP, which is equally efficient, but generates the extremely toxic and carcinogenic HMPA as a by-product in situ. PyBOP is generally preferred over BOP because it gives comparable performances but generates a less toxic by-product.Fórmula:C18H28N6OP·PF6Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:520.39 g/molPyBOP
CAS:((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)Fórmula:C18H28F6N6OP2Pureza:98%Peso molecular:520.39
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