CAS 136676-91-0

S-(+)-1-[(4-(Dimetilamino)-3-metilfenil)metil]-5-(difenilacetil)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridina-6-ácido carboxílico hidrato di(trifluoroacetato) sal

Descrição:

S-(+)-1-[(4-(Dimetilamino)-3-metilfenil)metil]-5-(difenilacetil)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridina-6-ácido carboxílico hidrato di(trifluoroacetato) sal, com número CAS 136676-91-0, é um composto orgânico complexo caracterizado por sua estrutura única de imidazopiridina, que incorpora uma estrutura de tetrahidro. Esta substância apresenta um grupo funcional ácido carboxílico, contribuindo para suas propriedades ácidas, e é ainda modificada pela presença de um grupo dimetilamino e um moiety de difenilacetila, que podem influenciar sua atividade farmacológica. A forma de sal trifluoroacetato sugere maior solubilidade e estabilidade, tornando-a adequada para várias aplicações, particularmente em química medicinal. A quiralidade do composto, indicada pela designação S-(+), implica que pode exibir atividade biológica específica, potencialmente afetando sua interação com alvos biológicos. No geral, a estrutura intrincada deste composto e seus grupos funcionais sugerem uma utilidade potencial no desenvolvimento de medicamentos, particularmente no contexto da neurofarmacologia ou como agente terapêutico.

Fórmula: C₃₁H₃₂N₄O₃₂C₂HF₃O₂

Sinónimos:

• PD 123,319 hydrate di(trifluoroacetate) salt

PD 123319 ditrifluoroacetate

CAS: 136676-91-0

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

Fórmula: C₃₅H₃₄F₆N₄O₇

Pureza: 99%

Peso molecular: 736.66

Ref: IN-DG434990

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

CAS: 136676-91-0

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

Fórmula: C₃₅H₃₄F₆N₄O₇

Pureza: 99%

Peso molecular: 736.67

Ref: 54-PC1006303

1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-, 2,2,2-trifluoroacetate (1:2)

CAS: 136676-91-0

Fórmula: C₃₅H₃₄F₆N₄O₇

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 736.6575

Ref: IN-DA001274

PD 123319 ditrifluoroacetate

CAS: 136676-91-0

PD 123319 ditrifluoroacetate is a selective non-peptide AT2 receptor antagonist with IC50 of 34 nM.

Fórmula: C₃₅H₃₄F₆N₄O₇

Pureza: 98%

Cor e Forma: White Solid

Peso molecular: 736.66

Ref: TM-T12381

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

CAS: 136676-91-0

Pureza: 99%

Peso molecular: 736.6680298

Ref: 10-F869778

PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate

Produto Controlado

CAS: 130663-39-7, 136676-91-0

Applications A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
References Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);

Fórmula: C₃₁H₃₂N₄O₃·2C₂HF₃O₂·xH₂O

Cor e Forma: Neat

Peso molecular: 754.7

Ref: TR-P217475

PD 123,319 di(trifluoroacetate) salt hydrate

CAS: 136676-91-0

PD 123,319 di(trifluoroacetate) salt hydrate is a selective inhibitor of the neurokinin-1 receptor. In animal studies, PD 123,319 di(trifluoroacetate) salt hydrate has been shown to reduce hyperactivity and produce an antinociceptive effect by inhibiting the release of substance P from nerve terminals. The compound also has a protective effect on neurons and tissues in animals with traumatic brain injury. It also inhibits spontaneous pain behaviour in rats with cancer or experimental arthritis and reduces angiotensin-II induced hypertension in rats. br>br> PD 123,319 di(trifluoroacetate) salt hydrate binds to the neurokinin-1 receptor (NK1R). The NK1R is a G protein coupled receptor that is expressed on nociceptive neurons in the spinal cord and brainstem. NK1R activation induces the release of substance P from nerve terminals. Substance

Fórmula: C₃₁H₃₂N₄O₃•(C₂HF₃O₂)₂•(H₂O)x

Pureza: Min. 95%

Peso molecular: 736.66 g/mol

Ref: 3D-LFA67691