CAS 137281-23-3

Pemetrexed

Descrição:

Pemetrexed é um agente quimioterápico antifolato de múltiplos alvos, utilizado principalmente no tratamento de certos tipos de câncer, particularmente câncer de pulmão de células não pequenas e mesotelioma. Seu mecanismo de ação envolve a inibição de várias enzimas na via do folato, incluindo timidilato sintase, diidrofolato redutase e formiltransferase de ribonucleotídeo de glicinamida, que são cruciais para a síntese de DNA e a proliferação celular. Pemetrexed é administrado por via intravenosa e muitas vezes é dado em combinação com outros agentes quimioterápicos para aumentar sua eficácia. O medicamento é caracterizado por sua complexidade estrutural, apresentando um anel de pirimidina e múltiplos grupos funcionais que contribuem para sua atividade biológica. Efeitos colaterais comuns incluem mielossupressão, distúrbios gastrointestinais e fadiga, necessitando de monitoramento cuidadoso durante o tratamento. Além disso, os pacientes podem precisar de suplementação com ácido fólico e vitamina B12 para mitigar algumas das toxicidades do medicamento. No geral, Pemetrexed representa um avanço significativo na terapia direcionada ao câncer, demonstrando melhores resultados em populações específicas de pacientes.

Fórmula: C₂₀H₂₁N₅O₆

InChI: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1

Chave InChI: InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

SMILES: C(CC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O

Sinónimos:

• (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
• 1H-Pyrrolo[2,3-d]pyrimidine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H pyrodo[2,3-d]Pyrimidin-5-yl)ethyl]-benzoic Acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
• N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
• NSC 698037
• Pefloxacinmesylate Pharma-0549
• Pemetrexed
• Pemetrexed Acid
• disodium (2R)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

Pemetrexed

CAS: 137281-23-3, 1916503-69-9

Fórmula: C₂₀H₂₁N₅O₆

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Blue powder to crystal

Peso molecular: 427.42

Ref: 3B-P2288

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 99+%

Peso molecular: 427.41

Ref: IN-DG146899

Pemetrexed Hydrate

CAS: 137281-23-3

Pemetrexed Hydrate

Fórmula: C₂₀H₂₁N₅O₆

Pureza: >99%

Cor e Forma: Solid

Peso molecular: 427.41

Ref: 54-OR1030044

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 427.4106

Ref: IN-DA00131R

Pemetrexed

CAS: 137281-23-3

Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 98.1% - 99.92%

Cor e Forma: Solid

Peso molecular: 427.41

Ref: TM-T0189

Pemetrexed

CAS: 137281-23-3

Pemetrexed

Fórmula: C₂₀H₂₁N₅O₆

Pureza: ≥98%

Peso molecular: 427.41

Ref: 54-BUP17815

Pemetrexed

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Cor e Forma: White To Off-White Solid

Peso molecular: 427.42

Ref: 4Z-P-681

Pemetrexed

CAS: 137281-23-3

Fórmula: C₂₀H₂₁N₅O₆

Peso molecular: 427.42

Ref: ST-EA-CP-P16000

Pemetrexed

CAS: 137281-23-3

Thymidylate synthase inhibitor; antifolate antineoplastic agent

Fórmula: C₂₀H₂₁N₅O₆

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 427.41 g/mol

Ref: 3D-FP37935

Pemetrexed

CAS: 137281-23-3

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

Fórmula: C₂₀H₂₁N₅O₆

Pureza: 98% +(contains <4%EtOH)(Loss on drying≤6%)

Peso molecular: 427.41

Ref: IN-DG01386674

Pemetrexed (Standard)

CAS: 137281-23-3

Pemetrexed (Standard) is a reference standard for research and analysis in studies involving Pemetrexed. Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Fórmula: C₂₀H₂₁N₅O₆

Cor e Forma: Solid

Peso molecular: 427.41

Ref: TM-TMSM-3442

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid

Produto Controlado

CAS: 137281-23-3

Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).
References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);

Fórmula: C₂₀H₂₁N₅O₆

Cor e Forma: Neat

Peso molecular: 427.41

Ref: TR-A604980

Pemetrexed - Bio-X ™

CAS: 137281-23-3

Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. It is used for the treatment of various cancers such as non-small cell lung cancer and pleural mesothelioma. Pemetrexed targets the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. The drug works by inhibiting those enzymes so that the formation of DNA and RNA is prevented.

Fórmula: C₂₀H₂₁N₅O₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 427.41 g/mol

Ref: 3D-BP164240