CAS 1397-89-3

Anfotericina B

Descrição:

Anfotericina B é um agente antifúngico polieno usado principalmente para tratar infecções fúngicas graves, particularmente aquelas causadas por espécies de Candida e Aspergillus. É derivado da bactéria Streptomyces nodosus e é conhecido por sua capacidade de se ligar ao ergosterol, um componente chave das membranas celulares fúngicas, levando à interrupção da membrana celular e, em última instância, à morte celular. Anfotericina B é caracterizado por sua cor marrom-amarelada e é tipicamente administrado por via intravenosa devido à sua baixa biodisponibilidade oral. Tem um peso molecular relativamente alto e é solúvel em dimetilsulfóxido (DMSO) e outros solventes orgânicos, mas pouco solúvel em água. O medicamento é conhecido por seus potenciais efeitos colaterais, incluindo nefrotoxicidade e reações relacionadas à infusão, o que exige monitoramento cuidadoso durante o tratamento. Anfotericina B é frequentemente usado em casos graves onde outros tratamentos antifúngicos podem ser ineficazes, tornando-se uma opção crítica no manejo de infecções fúngicas invasivas.

Fórmula: C₄₇H₇₃NO₁₇

InChI: InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

Chave InChI: InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N

SMILES: C(O)(=O)[C@H]1[C@]2(O[C@@](O)(C[C@@H]1O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C2)[H]

Sinónimos:

• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
• Abelcet
• Abelecet
• AmBisome
• Ampho-Moronal
• Amphocin
• Amphozone
• Apothecon
• Fungilin
• Fungizona
• Fungizone
• Halizon
• Kalsome 10
• LNS-AmB
• Ns 718
• Nsc 527017
• amfotericina B
• amphotericine B
• Amphotericin B
• 17,37-octahydroxy-15,16,18-trimethyl-13-oxo-(1r-(1r*,3s*,5r*,6r*,9r*,11r*,15s*
• 14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
• AMPHOTERICIN B, STREPTOMYCES NODOSUS
• AMPHOTERICIN B, STREPTOMYCES SPECIES
• FUNGIZONE(R)
• AMPHOTERCIN B
• amphotericineb
• AMPHOTERICIN B SOLUBILIZED
• 33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci
• 33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• AMPHOTERICIN B, SOLUBLE
• amphomoronal
• ,16r*,17r*,18s*,19e,21e,23e,25e-27e,29e,31e,33r*,35s*,36r*,37s*))-

Amphotericin B, 250 &mu;g/mL in distilled water, sterile-filtered

CAS: 1397-89-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67049

Amphotericin B, Streptomyces nodosus

CAS: 1397-89-3

Amphotericin B, Streptomyces nodosus, 1397-89-3, is a polyene with antibiotic properties which alters cell membrane permeability, leading to lysis and cell death. Learn more.

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.09

Ref: 02-J61491

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-Y0001014

AMPHOTERICIN B CRS

CAS: 1397-89-3

AMPHOTERICIN B CRS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-Y0000005

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

CAS: 1397-89-3

AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-Y0001361

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

CAS: 1397-89-3

SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-ISA_29078

AMPHOTERICIN B RS

CAS: 1397-89-3

AMPHOTERICIN B RS

Fórmula: C₄₇H₇₃NO₁₇

Peso molecular: 924.079

Ref: 41-ICRS0210

Amphotericin B

CAS: 1397-89-3

Antibiotics nesoi

Fórmula: C₄₇H₇₃NO₁₇

Cor e Forma: Yellow Orange Powder

Peso molecular: 923.48785

Ref: 45-1032007

Amphotericin B

CAS: 1397-89-3

Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 99.75% - ≥98%

Cor e Forma: Deep Yellow Prisms Or Needles From N N-Dimethylformamide Physical Description Bright Yellow Powder (Ntp 1992)

Peso molecular: 924.08

Ref: TM-T1067

AmphotericinB

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 924.0790

Ref: IN-DA00ILH6

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Cor e Forma: Yellow Solid

Peso molecular: 924.09

Ref: 4Z-A-137002

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: ≥ 750μg/mg (C47H73NO17, dried basis)

Cor e Forma: Yellow to dark yellow or orange powder

Peso molecular: 924.10

Ref: 7W-GA8986

Amphotericin B, Ph. Eur. grade

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: ≤ 2.0% (at 383nm)

Cor e Forma: Yellow or orange powder

Peso molecular: 924.10

Ref: 7W-GA2492

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Fórmula: C₄₇H₇₃NO₁₇

Cor e Forma: yellow powder

Peso molecular: 924.07902g/mol

Ref: 54-BIA0103

Amphotericin B

CAS: 1397-89-3

Amphotericin B

Pureza: ≥98%

Peso molecular: 924.08g/mol

Ref: 54-BUP15128

Amphotericin B

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: >80.0%(HPLC)

Cor e Forma: White to Light orange to Yellow powder to crystal

Peso molecular: 924.09

Ref: 3B-A2114

Amphotericin B

Produto Controlado

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Cor e Forma: Neat

Peso molecular: 924.08

Ref: 04-C10243050

Amphotericin B (85%)

CAS: 1397-89-3

Fórmula: C₄₇H₇₃NO₁₇

Pureza: 85%

Cor e Forma: Yellow

Peso molecular: 924.08

Ref: TR-A634250

Amphotericin B - Bio-X ™

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely occurs. Amphotericin B is a polyene antifungal that binds to fungal cell membrane, i.e., ergosterol disrupts the membrane permeability leading to leakage of intracellular components. It is often used as an alternative therapy for leishmaniasis and to treat severe mycoses including: systemic Candida, Cryptococcus, blastomycosis, and histoplasmosis.

Fórmula: C₄₇H₇₃NO₁₇

Pureza: Min. 75.0%

Cor e Forma: Powder

Peso molecular: 924.08 g/mol

Ref: 3D-AA15700

Amphotericin B, Antibiotic for Culture Media Use Only

CAS: 1397-89-3

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is exerted by interacting with the fungal membrane, mainly ergosterol, and inducing pore formation. The increase in membrane permeability causes loss of ions and cell death. The C-2’ hydroxyl residue of the mycosamine carbohydrate moiety in the structure seems to have a major role in binding to ergosterol. It is used in cell culture to prevent growth of microbial contaminants, such as yeast and fungi. It is recommended by the WHO and CDC as an antifungal component for VTM at a concentration of 250ug/ml.

Fórmula: C₄₇H₇₃NO₁₇

Pureza: Min. 80.0 Area-%

Peso molecular: 924.08 g/mol

Ref: 3D-A-7680