CAS 1397-89-3
:Anfotericina B
Descrição:
Anfotericina B é um agente antifúngico polieno usado principalmente para tratar infecções fúngicas graves, particularmente aquelas causadas por espécies de Candida e Aspergillus. É derivado da bactéria Streptomyces nodosus e é conhecido por sua capacidade de se ligar ao ergosterol, um componente chave das membranas celulares fúngicas, levando à interrupção da membrana celular e, em última instância, à morte celular. Anfotericina B é caracterizado por sua cor marrom-amarelada e é tipicamente administrado por via intravenosa devido à sua baixa biodisponibilidade oral. Tem um peso molecular relativamente alto e é solúvel em dimetilsulfóxido (DMSO) e outros solventes orgânicos, mas pouco solúvel em água. O medicamento é conhecido por seus potenciais efeitos colaterais, incluindo nefrotoxicidade e reações relacionadas à infusão, o que exige monitoramento cuidadoso durante o tratamento. Anfotericina B é frequentemente usado em casos graves onde outros tratamentos antifúngicos podem ser ineficazes, tornando-se uma opção crítica no manejo de infecções fúngicas invasivas.
Fórmula:C47H73NO17
InChI:InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
Chave InChI:InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N
SMILES:C(O)(=O)[C@H]1[C@]2(O[C@@](O)(C[C@@H]1O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C2)[H]
Sinónimos:- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- Abelcet
- Abelecet
- AmBisome
- Ampho-Moronal
- Amphocin
- Amphozone
- Apothecon
- Fungilin
- Fungizona
- Fungizone
- Halizon
- Kalsome 10
- LNS-AmB
- Ns 718
- Nsc 527017
- amfotericina B
- amphotericine B
- Amphotericin B
- 17,37-octahydroxy-15,16,18-trimethyl-13-oxo-(1r-(1r*,3s*,5r*,6r*,9r*,11r*,15s*
- 14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
- AMPHOTERICIN B, STREPTOMYCES NODOSUS
- AMPHOTERICIN B, STREPTOMYCES SPECIES
- FUNGIZONE(R)
- AMPHOTERCIN B
- amphotericineb
- AMPHOTERICIN B SOLUBILIZED
- 33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci
- 33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- AMPHOTERICIN B, SOLUBLE
- amphomoronal
- ,16r*,17r*,18s*,19e,21e,23e,25e-27e,29e,31e,33r*,35s*,36r*,37s*))-
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Amphotericin B
CAS:Fórmula:C47H73NO17Pureza:>80.0%(HPLC)Cor e Forma:White to Light orange to Yellow powder to crystalPeso molecular:924.09Amphotericin B, Streptomyces nodosus
CAS:Amphotericin B, Streptomyces nodosus, 1397-89-3, is a polyene with antibiotic properties which alters cell membrane permeability, leading to lysis and cell death. Learn more.Fórmula:C47H73NO17Peso molecular:924.09Amphotericin B, 250 μg/mL in distilled water, sterile-filtered
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo SciAMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS
CAS:AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRSFórmula:C47H73NO17Peso molecular:924.079SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B
CAS:SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN BFórmula:C47H73NO17Peso molecular:924.079AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS
CAS:AMPHOTERICIN B FOR PEAK IDENTIFICATION CRSFórmula:C47H73NO17Peso molecular:924.079Amphotericin B
CAS:Antibiotics nesoiFórmula:C47H73NO17Cor e Forma:Yellow Orange PowderPeso molecular:923.48785Amphotericin B
CAS:Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.Fórmula:C47H73NO17Pureza:99.75% - ≥98%Cor e Forma:Deep Yellow Prisms Or Needles From N N-Dimethylformamide Physical Description Bright Yellow Powder (Ntp 1992)Peso molecular:924.08Amphotericin B
CAS:Fórmula:C47H73NO17Pureza:≥ 750μg/mg (C47H73NO17, dried basis)Cor e Forma:Yellow to dark yellow or orange powderPeso molecular:924.10Amphotericin B, Ph. Eur. grade
CAS:Fórmula:C47H73NO17Pureza:≤ 2.0% (at 383nm)Cor e Forma:Yellow or orange powderPeso molecular:924.10Amphotericin B - Bio-X ™
CAS:Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely occurs. Amphotericin B is a polyene antifungal that binds to fungal cell membrane, i.e., ergosterol disrupts the membrane permeability leading to leakage of intracellular components. It is often used as an alternative therapy for leishmaniasis and to treat severe mycoses including: systemic Candida, Cryptococcus, blastomycosis, and histoplasmosis.
Fórmula:C47H73NO17Pureza:Min. 75.0%Cor e Forma:PowderPeso molecular:924.08 g/mol
