CAS 1397-89-3
:Anfotericina B
Descrição:
Anfotericina B é um agente antifúngico polieno usado principalmente para tratar infecções fúngicas graves, particularmente aquelas causadas por espécies de Candida e Aspergillus. É derivado da bactéria Streptomyces nodosus e é conhecido por sua capacidade de se ligar ao ergosterol, um componente chave das membranas celulares fúngicas, levando à interrupção da membrana celular e, em última instância, à morte celular. Anfotericina B é caracterizado por sua cor marrom-amarelada e é tipicamente administrado por via intravenosa devido à sua baixa biodisponibilidade oral. Tem um peso molecular relativamente alto e é solúvel em dimetilsulfóxido (DMSO) e outros solventes orgânicos, mas pouco solúvel em água. O medicamento é conhecido por seus potenciais efeitos colaterais, incluindo nefrotoxicidade e reações relacionadas à infusão, o que exige monitoramento cuidadoso durante o tratamento. Anfotericina B é frequentemente usado em casos graves onde outros tratamentos antifúngicos podem ser ineficazes, tornando-se uma opção crítica no manejo de infecções fúngicas invasivas.
Fórmula:C47H73NO17
InChI:InChI=1/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
Chave InChI:InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N
SMILES:C(O)(=O)[C@H]1[C@]2(O[C@@](O)(C[C@@H]1O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C2)[H]
Sinónimos:- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-<span class="text-smallcaps">D</span>-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- 14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylicacid, 33-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-,(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-
- Abelcet
- Abelecet
- AmBisome
- Ampho-Moronal
- Amphocin
- Amphozone
- Apothecon
- Fungilin
- Fungizona
- Fungizone
- Halizon
- Kalsome 10
- LNS-AmB
- Ns 718
- Nsc 527017
- amfotericina B
- amphotericine B
- Amphotericin B
- 17,37-octahydroxy-15,16,18-trimethyl-13-oxo-(1r-(1r*,3s*,5r*,6r*,9r*,11r*,15s*
- 14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
- AMPHOTERICIN B, STREPTOMYCES NODOSUS
- AMPHOTERICIN B, STREPTOMYCES SPECIES
- FUNGIZONE(R)
- AMPHOTERCIN B
- amphotericineb
- AMPHOTERICIN B SOLUBILIZED
- 33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci
- 33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- AMPHOTERICIN B, SOLUBLE
- amphomoronal
- ,16r*,17r*,18s*,19e,21e,23e,25e-27e,29e,31e,33r*,35s*,36r*,37s*))-
- Ver mais sinónimos
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Amphotericin B
CAS:Fórmula:C47H73NO17Pureza:>80.0%(HPLC)Cor e Forma:White to Light orange to Yellow powder to crystalPeso molecular:924.09Amphotericin B, Streptomyces nodosus
CAS:Amphotericin B, Streptomyces nodosus, 1397-89-3, is a polyene with antibiotic properties which alters cell membrane permeability, leading to lysis and cell death. Learn more.Fórmula:C47H73NO17Peso molecular:924.09Amphotericin B, 250 μg/mL in distilled water, sterile-filtered
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo SciAMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRS
CAS:AMPHOTERICIN B FOR MICROBIOLOGICAL ASSAY CRSFórmula:C47H73NO17Peso molecular:924.079AMPHOTERICIN B FOR PEAK IDENTIFICATION CRS
CAS:AMPHOTERICIN B FOR PEAK IDENTIFICATION CRSFórmula:C47H73NO17Peso molecular:924.079SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN B
CAS:SECOND INTERNATIONAL STANDARD FOR AMPHOTERICIN BFórmula:C47H73NO17Peso molecular:924.079Amphotericin B
CAS:Antibiotics nesoiFórmula:C47H73NO17Cor e Forma:Yellow Orange PowderPeso molecular:923.48785Amphotericin B
CAS:Amphotericin B (NSC-527017) is a polyene antifungal agent with broad-spectrum activity against many fungal species.Fórmula:C47H73NO17Pureza:99.75% - ≥98%Cor e Forma:Yellow SolidPeso molecular:924.08Amphotericin B, Ph. Eur. grade
CAS:Fórmula:C47H73NO17Pureza:≤ 2.0% (at 383nm)Cor e Forma:Yellow or orange powderPeso molecular:924.10Amphotericin B
CAS:Fórmula:C47H73NO17Pureza:≥ 750μg/mg (C47H73NO17, dried basis)Cor e Forma:Yellow to dark yellow or orange powderPeso molecular:924.10Amphotericin B
CAS:Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is exerted by interacting with the fungal membrane, mainly ergosterol, and inducing pore formation. The increase in membrane permeability causes loss of ions and cell death. The C-2 hydroxyl residue of the mycosamine carbohydrate moiety in the structure seems to have a major role in binding to ergosterol. It is used in cell culture to prevent growth of microbial contaminants, such as yeast and fungi. It is recommended by the WHO and CDC as an antifungal component for VTM at a concentration of 250ug/ml.Fórmula:C47H73NO17Cor e Forma:Yellow PowderPeso molecular:924.08 g/mol
