CAS 1404-93-9

Vancomicina, cloridrato

Descrição:

A vancomicina hidroclorídrica é um antibiótico glicopeptídico usado principalmente para tratar infecções bacterianas graves, particularmente aquelas causadas por bactérias Gram-positivas, incluindo Staphylococcus aureus resistente à meticilina (MRSA). É caracterizada por sua estrutura complexa, que inclui uma série de aminoácidos e grupos de açúcar que contribuem para seu mecanismo de ação. A vancomicina atua inibindo a síntese da parede celular nas bactérias, levando à lise celular e morte. A forma hidroclorídrica melhora sua solubilidade em água, tornando-a adequada para administração intravenosa. Geralmente é administrada em um ambiente clínico devido à sua potência e à necessidade de monitorar potenciais efeitos colaterais, como nefrotoxicidade e ototoxicidade. A vancomicina também é notável por seu espectro de atividade, que é limitado a certos tipos de bactérias, e muitas vezes é reservada para casos em que outros antibióticos são ineficazes. Seu uso é guiado por testes de suscetibilidade para garantir a eficácia e combater o desenvolvimento de resistência a antibióticos.

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·xClH

InChI: InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

Chave InChI: InChIKey=LCTORFDMHNKUSG-XTTLPDOESA-N

SMILES: O(C=1C2=CC3=CC1OC=4C(Cl)=CC(=CC4)[C@@H](O)[C@@H](NC([C@@H](CC(C)C)NC)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@]3(C(=O)N[C@@]5(C=6C=C(C=7C([C@@H](C(O)=O)NC(=O)[C@]([C@H](O)C=8C=C(Cl)C(O2)=CC8)(NC5=O)[H])=CC(O)=CC7O)C(O)=CC6)[H])[H])[C@H]9[C@H](O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)[C@@H](O)[C@H](O)[C@@H](CO)O9.Cl

Sinónimos:

• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (non-preferred name)
• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid (non-preferred name)
• (3S-(3R*,6S*(S*),7S*,22S*,23R*,26R*,36S*,38aS*))-3-(2-Amino-2-oxoethyl)-44-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid, monohydrochloride
• 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv.
• 48-({3-[(4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl}oxy)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (1:1) (non-preferred name)
• Laikexin
• Lyphocin
• Unii-71Wo621Tjd
• Vancocin hydrochloride
• Vancocine hydrochloride
• Vancocyn
• Vancomycin HCl
• Vancomycin monohydrochloride
• Vancor

Vancomycin hydrochloride, Molecular Biology Grade

CAS: 1404-93-9

Vancomycin hydrochloride, 1404-93-9, is a polypeptide with antibiotic properties suitable for laboratory study of bacterial infections. Learn more at Thermo Fisher Scientific.

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Cor e Forma: White to tan to brown, Free-flowing powder

Peso molecular: 1485.72

Ref: 02-J62790

Vancomycin hydrochloride, 50 mg/ml in distilled water, sterile-filtered

CAS: 1404-93-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67251

Vancomycin Hydrochloride

CAS: 1404-93-9

Cor e Forma: Off White Solid

Ref: 61-FOR0239.00

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

CAS: 1404-93-9

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄

Peso molecular: 1449.254

Ref: 41-ISA_39036

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

CAS: 1404-93-9

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002080

VANCOMYCIN HYDROCHLORIDE CRS

CAS: 1404-93-9

VANCOMYCIN HYDROCHLORIDE CRS

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄

Cor e Forma: White. Powder.

Peso molecular: 1449.254

Ref: 41-V0045000

Vancomycin B with Monodechlorovancomycin

CAS: 1404-93-9

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Cor e Forma: Off-White Tan Powder

Peso molecular: 1483.40688

Ref: 45-1709018

Vancomycin B

CAS: 1404-93-9

Antibiotics nesoi

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Cor e Forma: White Brown Powder

Peso molecular: 1483.40688

Ref: 45-1709029

Vancomycin, hydrochloride

CAS: 1404-93-9

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 1485.7145

Ref: IN-DA001CD1

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride (Vancomycin HCl) targets peptidoglycan in bacterial cell wall synthesis. High-Quality, Low-Cost!

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Pureza: 97.20% - 99.19%

Cor e Forma: Off White Powder

Peso molecular: 1485.71

Ref: TM-T0832

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Pureza: Heavy metals: <30 ppm. (Typical Value in Batch COA)

Cor e Forma: white. almost white or tan to brown free flowing powder

Peso molecular: 1,485.71g/mol

Ref: 54-BIV0155

Vancomycin hydrochloride, low endotoxin

CAS: 1404-93-9

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Pureza: ≤ 5.0%

Cor e Forma: White to tan powder

Peso molecular: 1485.73

Ref: 7W-GP4819

Vancomycin hydrochloride

CAS: 1404-93-9

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Pureza: ≤ 5.0%

Cor e Forma: White to tan powder

Peso molecular: 1485.73

Ref: 7W-GA6284

Vancomycin hydrochloride BioChemica

CAS: 1404-93-9

Vancomycin hydrochloride BioChemica

Cor e Forma: Solid

Peso molecular: 1,485.71g/mol

Ref: 54-BIA1839

Vancomycin hydrochloride

Produto Controlado

CAS: 1404-93-9

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Cor e Forma: Neat

Peso molecular: 1485.71

Ref: 04-C17900500

Vancomycin Hydrochloride

Produto Controlado

CAS: 1404-93-9

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Cor e Forma: Neat

Peso molecular: 1485.71

Ref: 86-MM0239.00

Vancomycin solution

CAS: 1404-93-9

Vancomycin solution

Cor e Forma: Solution

Peso molecular: 1,485.71g/mol

Ref: 54-BIG1035

Vancomycin Hydrochloride RS

CAS: 1404-93-9

Cor e Forma: White Solid Powder

Ref: 2K-7000800021

Vancomycin Hydrochloride (90%)

CAS: 1404-93-9

Stability Hygroscopic
Applications Vancomycin Hydrochloride is an antibiotic used against gram-positive bacterial strains.
References Yao, N., et al.: Biopolymers, 90, 421 (2008); Lai, H., et al.: ACS Appl. Mater. Interfaces, 7, 2046 (2015);

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Pureza: 90%

Cor e Forma: Neat

Peso molecular: 1485.71

Ref: TR-V096533

Vancomycin HCl - pharma grade

CAS: 1404-93-9

Vancomycin is a tricyclic glycopeptide antibiotic that has bactericidal effects against staphylococci, streptococci, and other gram-positive bacteria. It is often used as an alternative treatment for severe staphylococcal and streptococcal infections, including endocarditis, and infections with MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci or in cases of allergy to penicillins and cephalosporins.

Fórmula: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Cor e Forma: Powder

Peso molecular: 1,485.71 g/mol

Ref: 3D-AV11352

Vancomycin hydrochloride

CAS: 1404-93-9

Inhibitor of cell wall biogenesis; glycopeptide antibiotic

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Pureza: Min. 88 Area-%

Cor e Forma: Powder

Peso molecular: 1,485.71 g/mol

Ref: 3D-AV161115

Vancomycin hydrochloride (1:1)

CAS: 1404-93-9

Vancomycin hydrochloride (1:1) is a glycopeptide antibiotic with action on bacterial cell wall synthesis and is used for treating severe bacterial infections like septicemia, endocarditis, and skin infections.

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,485.72 g/mol

Ref: 3D-XHA63825

Vancomycin hydrochloride, Antibiotic for Culture Media Use Only

CAS: 1404-93-9

Vancomycin hydrochloride is an antibiotic that is used against Gram-positive bacteria, including Staphylococcus aureus. It has been shown to inhibit the growth of bacteria by binding the D-alanyl-D-alanine moiety of the peptidoglycan cell wall precursor, inhibiting the peptidoglycan synthesis and disrupting its cross linking. It also inhibits particle formation when it reacts with human plasma, which can lead to hemolysis and hemagglutination. The absorption spectrum for vancomycin hydrochloride shows maxima at 230, 260, 290, and 320 nm, which are characteristic for this compound. Vancomycin has been used in several studies for treatment of methicillin-resistant Staphylococcus aureus infections.

Fórmula: C₆₆H₇₆Cl₃N₉O₂₄

Peso molecular: 1,485.71 g/mol

Ref: 3D-Q-201920

Vancomycin Hydrochloride (VNC), 90%

CAS: 1404-93-9

Fórmula: C₆₆H₇₅CI₂N₉O₂₄·HCI

Pureza: min. 90%

Cor e Forma: Off white to Light pink to Orange brown, Crystalline powder, Clear

Peso molecular: 1485.73

Ref: SR-61078