CAS 147664-63-9

Pexiganan

Descrição:

Pexiganan é um peptídeo antimicrobiano sintético que é utilizado principalmente por suas propriedades antibacterianas, particularmente contra bactérias Gram-negativas. É derivado da família de peptídeos magainina, que ocorrem naturalmente na pele de certos anfíbios. Pexiganan exibe um amplo espectro de atividade, tornando-o eficaz no tratamento de infecções, especialmente em formulações tópicas para feridas. O mecanismo de ação envolve a interrupção das membranas celulares bacterianas, levando à lise celular. Este peptídeo é caracterizado por seu tamanho relativamente pequeno, consistindo tipicamente de cerca de 22 aminoácidos, e sua natureza catiônica, que melhora sua interação com membranas bacterianas carregadas negativamente. Pexiganan também é notável por sua estabilidade e resistência à degradação proteolítica, o que contribui para sua eficácia em aplicações clínicas. Seu desenvolvimento tem se concentrado particularmente em abordar a crescente preocupação com a resistência a antibióticos, fornecendo uma abordagem alternativa às terapias antibióticas tradicionais. No geral, Pexiganan representa um candidato promissor no campo de agentes antimicrobianos, particularmente para uso tópico.

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

InChI: InChI=1/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1

Chave InChI: KGZGFSNZWHMDGZ-KAYYGGFYSA-N

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O

Sinónimos:

• Pexiganan [INN]
• Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide
• Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide
• L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan

CAS: 147664-63-9

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Cor e Forma: Solid

Peso molecular: 2477.17

Ref: TM-T73653

L-Lysinamide,glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

CAS: 147664-63-9

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Pureza: 99.78%

Peso molecular: 2477.174

Ref: IN-DA00ANGD

Pexiganan acetate

Produto Controlado

CAS: 147664-63-9

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂•(C₂H₄O₂)x

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 2,477.18 g/mol

Ref: 3D-FP182746

Pexiganan

CAS: 147664-63-9

Pexiganan is a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Fórmula: C₁₂₂H₂₁₀N₃₂O₂₂

Pureza: Min. 95%

Peso molecular: 2,477.18 g/mol

Ref: 3D-FP138116