CAS 152520-56-4

Cloridrato de nebivolol

Descrição:

Cloridrato de nebivolol é um bloqueador seletivo dos receptores adrenérgicos beta-1, utilizado principalmente no tratamento da hipertensão e insuficiência cardíaca. É caracterizado pela sua capacidade de reduzir a pressão arterial, diminuindo a frequência cardíaca e a contratilidade miocárdica, reduzindo assim o débito cardíaco. O nebivolol é único entre os beta-bloqueadores devido às suas propriedades vasodilatadoras, que são atribuídas à sua capacidade de estimular a liberação de óxido nítrico, levando a uma melhora da função endotelial. A substância é tipicamente administrada por via oral e é bem absorvida, com um perfil farmacocinético favorável que inclui uma longa meia-vida, permitindo a dosagem uma vez ao dia. Cloridrato de nebivolol é geralmente bem tolerado, com um perfil de efeitos colaterais que pode incluir dor de cabeça, fadiga e distúrbios gastrointestinais. Sua estrutura química inclui um centro quiral, resultando em diferentes efeitos farmacológicos entre seus enantiômeros. No geral, Cloridrato de nebivolol representa uma abordagem moderna para o manejo de condições cardiovasculares, combinando eficácia com um perfil de segurança relativamente favorável.

Fórmula: C₂₂H₂₅F₂NO₄·ClH

InChI: InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/s2

Chave InChI: InChIKey=JWEXHQAEWHKGCW-NJEBDULONA-N

SMILES: [C@@H](CNC[C@H](O)[C@]1(OC=2C(CC1)=CC(F)=CC2)[H])(O)[C@@]3(OC=4C(CC3)=CC(F)=CC4)[H].Cl

Sinónimos:

• 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, (αR,α′R,2R,2′S)-rel-
• 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-
• Lobivon
• Nebicard
• Nebilet
• Nebilox
• Nebivolol hcl
• Nebivololhydrochloride(Subjecttopatentfree)
• Nodon
• R 067555
• R-67555
• Rac Nebivolol, Hydrochloride
• a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
• NEBIVOLOL HC
• Nebivolol (Bystolic)
• alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• D06622
• a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• Nebivolol hydrochloride (usan)
• Nebivolol hydrochloride, >=98%
• (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
• (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
• rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
• Nebivolol hydrochloride
• Bystolic
• Narbivolol

Nebivolol Hydrochloride

CAS: 152520-56-4

Cor e Forma: Neat

Ref: 61-FOR0947.00

NEBIVOLOL HYDROCHLORIDE CRS

CAS: 152520-56-4

NEBIVOLOL HYDROCHLORIDE CRS

Cor e Forma: Added

Ref: 41-Y0002299

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

CAS: 152520-56-4

NEBIVOLOL FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002306

Nebivolol Hydrochloride

CAS: 152520-56-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Cor e Forma: White Off-White Powder

Peso molecular: 441.15184

Ref: 45-1457833

Nebivolol Hydrochloride

CAS: 152520-56-4

Nebivolol Hydrochloride

Fórmula: C₂₂H₂₆ClF₂NO₄

Pureza: 98%

Peso molecular: 441.9

Ref: 54-PC108965

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: 99.77% - >99.99%

Cor e Forma: White Solid

Peso molecular: 441.90

Ref: TM-T0154

Nebivolol Hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₆ClF₂NO₄

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 441.8959

Ref: IN-DA007YL0

Nebivolol hydrochloride

CAS: 152520-56-4

Nebivolol hydrochloride

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: ≥98%

Peso molecular: 441.9

Ref: 54-BUP15662

Nebivolol hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: ≥ 98.0% (anhydrous basis)

Cor e Forma: White to off-white crystalline powder

Peso molecular: 441.90

Ref: 7W-GP6004

Nebivolol HCl

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 405.45 36.46

Ref: 4Z-N-201

Nebivolol Hydrochloride

Produto Controlado

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Cor e Forma: Neat

Peso molecular: 441.90

Ref: 86-MM0947.00

Nebivolol hydrochloride (Standard)

CAS: 152520-56-4

Nebivolol hydrochloride (Standard) is the standard substance of Nebivolol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Peso molecular: 441.90

Ref: TM-TMSM-1712

Nebivolol hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Cor e Forma: Neat

Peso molecular: 441.90

Ref: 04-C15499900

Nebivolol Hydrochloride

CAS: 118457-14-0, 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 441.90

Ref: 3B-N0954

Nebivolol Hydrochloride

CAS: 152520-56-4

Fórmula: C₂₂H₂₅F₂NO₄HCl

Peso molecular: 405.4 : 36.46

Ref: ST-EA-CP-N5020

Nebivolol Hydrochloride

CAS: 152520-56-4

Applications Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.
References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990);

Fórmula: C₂₂H₂₅F₂NO₄·ClH

Cor e Forma: Neat

Peso molecular: 441.9

Ref: TR-N387935

Nebivolol HCl - Bio-X ™

Produto Controlado

CAS: 152520-56-4

Nebivolol is a beta-blocker that is used to treat high blood pressure. It is also used in the treatment of angina, to decrease the heart rate and contractile force. Nebivolol has weak beta-2 adrenergic receptor antagonist action but is a highly selective beta-1 adrenergic receptor antagonist. Nebivolol's ability to block beta-1 adrenergic receptors results in a reduction in myocardial contractility, systolic and diastolic blood pressure, resting heart rate, and workout heart rate.

Fórmula: C₂₂H₂₅F₂NO₄·HCl

Pureza: (%) Min. 95%

Cor e Forma: White/Off-White Solid

Peso molecular: 441.9 g/mol

Ref: 3D-BN164638

Nebivolol hydrochloride

Produto Controlado

CAS: 152520-56-4

Nebivolol HCl is a beta-blocker that is used to treat high blood pressure and heart failure. It is a prodrug that is metabolized in vivo to its active form, nebivolol. Nebivolol HCl has a low bioavailability of about 5%, which may be due to the presence of excipients or the formation of solid dispersions with other ingredients in the formulation. Nebivolol HCl also interacts with many drugs that are metabolized by CYP2D6, CYP3A4, and CYP1A2 enzymes, such as metoprolol succinate, sodium citrate, and hydrochloric acid. This drug also has an adverse effect on geriatric patients because it can cause dizziness due to orthostatic hypotension.

Fórmula: C₂₂H₂₅F₂NO₄•HCl

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 441.9 g/mol

Ref: 3D-FN36779