CAS 1554458-53-5

Fórmula: C27H24F5N5O3

InChI: InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)

Chave InChI: WNEILUNVMHVMPH-UHFFFAOYSA-N

SMILES: CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5

BAY1217389

CAS: 1554458-53-5

BAY1217389

Fórmula: C₂₇H₂₄F₅N₅O₃

Pureza: 99%

Peso molecular: 561.5

Ref: 54-BUP12171

N-Cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

CAS: 1554458-53-5

N-Cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

Fórmula: C₂₇H₂₄F₅N₅O₃

Pureza: 98%

Peso molecular: 561.5

Ref: IN-DG764566

BAY1217389

CAS: 1554458-53-5

BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).

Fórmula: C₂₇H₂₄F₅N₅O₃

Pureza: 98.14% - 99.04%

Cor e Forma: White Solid

Peso molecular: 561.5032

Ref: TM-T3434

BAY 12-17389

CAS: 1554458-53-5

BAY 12-17389 is a novel anticancer drug that inhibits the activity of CDK4 and CDK6. It is an imidazopyrazine derivative, which binds to the ATP-binding pocket of the enzyme, thereby preventing its activation. BAY 12-17389 has shown anticancer activity in animal models for skin cancer and bladder cancer. In vitro assays have demonstrated that BAY 12-17389 is effective at inhibiting proliferation of cultured cells from different types of human cancers. The effective dose for BAY 12-17389 is not yet known but it has been shown to be safe at doses as high as 2 µM.

Fórmula: C₂₇H₂₄F₅N₅O₃

Pureza: Min. 95%

Peso molecular: 561.5 g/mol

Ref: 3D-EMC45853

Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-

CAS: 1554458-53-5

Fórmula: C₂₇H₂₄F₅N₅O₃

Pureza: 98%

Peso molecular: 561.5032

Ref: IN-DA001NWW