CAS 158584-08-8

7-metoxicumarina-4-acetil-arg-pro-*lis-pro-tir-A

Descrição:

7-metoxicumarina-4-acetil-arg-pro-*lis-pro-tir-A, identificado pelo seu número CAS 158584-08-8, é um composto sintético que pertence à classe dos derivados de cumarina. As cumarinas são conhecidas por suas diversas atividades biológicas, incluindo propriedades anticoagulantes, anti-inflamatórias e antimicrobianas. Este composto em particular apresenta um grupo metóxi e um moiety acetil, que podem influenciar sua solubilidade e reatividade. A presença da sequência peptídica, que inclui aminoácidos como arginina, prolina, lisina e tirosina, sugere uma potencial bioatividade relacionada a interações peptídicas e vias de sinalização. As modificações estruturais podem melhorar seu perfil farmacológico, tornando-o um candidato para várias aplicações em química medicinal e desenvolvimento de medicamentos. Além disso, a estabilidade, solubilidade e interação do composto com alvos biológicos seriam fatores críticos na determinação de sua eficácia e segurança em contextos terapêuticos potenciais. Estudos adicionais seriam necessários para elucidar seus mecanismos específicos de ação e possíveis usos em ambientes de pesquisa ou clínicos.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

InChI: InChI=1/C79H105N19O19S/c1-5-15-57(71(104)93-62(39-48-44-86-54-17-7-6-16-52(48)54)74(107)91-58(31-37-118-4)72(105)89-56(69(81)102)18-9-11-33-84-55-30-25-49(97(112)113)42-65(55)98(114)115)90-70(103)45(2)87-73(106)61(38-46-23-26-50(99)27-24-46)94-76(109)64-22-14-36-96(64)78(111)60(19-8-10-32-80)92-75(108)63-21-13-35-95(63)77(110)59(20-12-34-85-79(82)83)88-67(100)40-47-41-68(101)117-66-43-51(116-3)28-29-53(47)66/h6-7,16-17,23-30,41-45,56-64,84,86,99H,5,8-15,18-22,31-40,80H2,1-4H3,(H2,81,102)(H,87,106)(H,88,100)(H,89,105)(H,90,103)(H,91,107)(H,92,108)(H,93,104)(H,94,109)(H4,82,83,85)/t45-,56-,57-,58-,59-,60?,61-,62-,63-,64-/m0/s1

SMILES: CCC[C@@H](C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CCCCNc1ccc(cc1N(=O)=O)N(=O)=O)C(=N)O)O)O)O)N=C([C@H](C)N=C([C@H](Cc1ccc(cc1)O)N=C([C@@H]1CCCN1C(=O)C(CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N=C(Cc1cc(=O)oc2cc(ccc12)OC)O)O)O)O)O

Sinónimos:

• Nff 2
• (7-Methoxycoumarin-4-yl)acetyl-arginyl-prolyl-lysyl-prolyl-tyrosyl-alanyl-norvalyl-tryptophyl-methionyl-(2,4-dinitrophenyl)lysinamide
• Mca-arg-pro-lys-pro-tyr-ala-nva-trp-met-lys(dnp)-NH2
• N2-((7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl)-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide
• L-Lysinamide, N2-((7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl)-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-
• L-Lysinamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-
• (7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE
• N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide
• 7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-tyr-A
• MCA-RPKPYA-NVA-WM-K(DNP)-NH2
• Mca-RPKPYA-Nva-WM-Lys(Dnp)-NH2
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-TYR-ALA
• 7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂

CAS: 158584-08-8

The FRET substrate Mca-RPKPYA-Nva-WMK(Dnp)-amide was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M⁻¹s⁻¹) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M⁻¹s⁻¹), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested this fluorogenic substrate with a kcat/Km of 243000 M⁻¹s⁻¹.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: > 95%

Cor e Forma: White Whitish Powder

Peso molecular: 1656.89

Ref: 01-4030841

7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-(2,4-dinitrophenyl)Lys amide

CAS: 158584-08-8

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Peso molecular: 1656.86

Ref: 7W-GK2677

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂

CAS: 158584-08-8

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ is a peptide that was designed to bind to ion channels. It is an activator of the nicotinic acetylcholine receptor. The peptide has also been shown to inhibit protein interactions and be a ligand for the serotonin receptor. MOCAc binds to the extracellular domain of the nicotinic acetylcholine receptor, which leads to a conformational change in the receptor's structure. This changes the shape of the channel, which allows potassium ions to flow out of the cell and sodium ions to flow in. MOCAc does not have any effects on other receptors or ion channels. MOCAc has been used as a research tool to study protein interactions and as an antibody for immunostaining and Western blotting as well as for cell biology studies.

Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: Min. 95%

Peso molecular: 1,656.9 g/mol

Ref: 3D-SMO-3167-V

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 trifluoroacetate salt

CAS: 158584-08-8

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Fórmula: C₇₉H₁₀₅N₁₉O₁₉S

Pureza: Min. 95%

Peso molecular: 1,656.86 g/mol

Ref: 3D-FM110915