CAS 1629268-00-3
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1-[3-[4-[2-[[4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-2-propen-1-one
CAS:Fórmula:C22H29ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:432.94371-(3-(4-((4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl)glycyl)piperazin-1-yl)azetidin-1-yl)prop-2-en-1-one
CAS:1-(3-(4-((4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl)glycyl)piperazin-1-yl)azetidin-1-yl)prop-2-en-1-oneFórmula:C22H29ClN4O3Pureza:98%Peso molecular:432.94ARS-853
CAS:ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFórmula:C22H29ClN4O3Pureza:97.43% - 98.4%Cor e Forma:SolidPeso molecular:432.944ARS-853
CAS:ARS-853 is a potent inhibitor of protein kinase C (PKC) and PKC-related enzymes. ARS-853 has been shown to be an activated, potent inhibitor of PKC in vivo in a mouse tumor model. The mechanism of inhibition is thought to be due to the binding of ARS-853 to the catalytic site of PKC, which blocks phosphatase activity. PKC inhibitors are used in cancer treatment because they help control cancer cell signaling pathways. ARS-853 has been shown to inhibit phosphatases, such as PTP1B, which regulate multiple cellular processes including glycogen synthesis, lipid metabolism, and insulin secretion.
Pharmacokinetic studies have shown that ARS-853 is rapidly absorbed from the gastrointestinal tract and eliminated primarily by hepatic metabolism with a half-life of about 2 hours.Fórmula:C22H29ClN4O3Pureza:Min. 95%Peso molecular:432.94 g/molRef: 3D-EQC26800
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