CAS 169590-42-5
:Celecoxib
Descrição:
Celecoxib é um medicamento anti-inflamatório não esteroidal (AINE) usado principalmente para o tratamento da dor e da inflamação associadas a condições como a artrite. Inibe seletivamente a enzima ciclooxigenase-2 (COX-2), que desempenha um papel fundamental no processo inflamatório, reduzindo assim a produção de prostaglandinas que mediam a dor e a inflamação. Celecoxib é caracterizado pela sua fórmula química C17H14F3N3O2S e um peso molecular de aproximadamente 381,37 g/mol. É tipicamente administrado por via oral e é conhecido por seus efeitos colaterais gastrointestinais relativamente menores em comparação com os AINEs tradicionais, pois preserva a enzima COX-1, que está envolvida na proteção da mucosa gástrica. Celecoxib também é reconhecido por seus potenciais riscos cardiovasculares, particularmente em uso a longo prazo, exigindo cuidadosa seleção e monitoramento dos pacientes. A substância é geralmente bem absorvida, com concentrações plasmáticas máximas ocorrendo dentro de algumas horas após a administração, e é metabolizada principalmente no fígado.
Fórmula:C17H14F3N3O2S
InChI:InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
Chave InChI:InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3
Sinónimos:- 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
- 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
- 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
- Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
- Celebra-
- Celebrex
- Celecox
- Celocoxib
- Eurocox
- Medicoxib
- Onsenal
- Sc 58635
- Xilebao
- Ym 177
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18 produtos.
Celecoxib
CAS:Fórmula:C17H14F3N3O2SPureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:381.37Celecoxib
CAS:Sulfonamides used as drugsFórmula:C17H14F3N3O2SCor e Forma:PowderPeso molecular:381.07588Celecoxib
CAS:Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.Fórmula:C17H14F3N3O2SPureza:99.44% - 99.98%Cor e Forma:White PowderPeso molecular:381.37Celecoxib
CAS:Fórmula:C17H14F3N3O2SPureza:(Titration) 98.0 - 102.0 % (dried basis)Cor e Forma:White or almost white powderPeso molecular:381.37Celecoxib
CAS:Produto Controlado<p>Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C17H14F3N3O2SCor e Forma:NeatPeso molecular:381.37Celecoxib
CAS:Produto ControladoCelecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib-BioX TM also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.Fórmula:C17H14F3N3O2SPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:381.37 g/molCelecoxib - Bio-X ™
CAS:Produto Controlado<p>Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.<br>Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C17H14F3N3O2SPureza:Min. 95%Cor e Forma:PowderPeso molecular:381.37 g/mol
