CAS 169590-42-5

Celecoxib

Descrição:

Celecoxib é um medicamento anti-inflamatório não esteroidal (AINE) usado principalmente para o tratamento da dor e da inflamação associadas a condições como a artrite. Inibe seletivamente a enzima ciclooxigenase-2 (COX-2), que desempenha um papel fundamental no processo inflamatório, reduzindo assim a produção de prostaglandinas que mediam a dor e a inflamação. Celecoxib é caracterizado pela sua fórmula química C17H14F3N3O2S e um peso molecular de aproximadamente 381,37 g/mol. É tipicamente administrado por via oral e é conhecido por seus efeitos colaterais gastrointestinais relativamente menores em comparação com os AINEs tradicionais, pois preserva a enzima COX-1, que está envolvida na proteção da mucosa gástrica. Celecoxib também é reconhecido por seus potenciais riscos cardiovasculares, particularmente em uso a longo prazo, exigindo cuidadosa seleção e monitoramento dos pacientes. A substância é geralmente bem absorvida, com concentrações plasmáticas máximas ocorrendo dentro de algumas horas após a administração, e é metabolizada principalmente no fígado.

Fórmula: C₁₇H₁₄F₃N₃O₂S

InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

Chave InChI: InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3

Sinónimos:

• 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
• 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
• 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
• Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
• Celebra-
• Celebrex
• Celecox
• Celocoxib
• Eurocox
• Medicoxib
• Onsenal
• Sc 58635
• Xilebao
• Ym 177

Celecoxib

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 381.37

Ref: 3B-C2816

Celecoxib

CAS: 169590-42-5

Celecoxib

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: 99.7%

Cor e Forma: White

Peso molecular: 381.07588

Ref: 47-1230

CELECOXIB CRS

CAS: 169590-42-5

CELECOXIB CRS

Ref: 41-Y0001445

Celecoxib

CAS: 169590-42-5

Sulfonamides used as drugs

Fórmula: C₁₇H₁₄F₃N₃O₂S

Cor e Forma: Powder

Peso molecular: 381.07588

Ref: 45-1098504

Celecoxib

CAS: 169590-42-5

Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: 99.44% - 99.98%

Cor e Forma: Solid

Peso molecular: 381.37

Ref: TM-T0466

Celecoxib

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Cor e Forma: White To Off-White Solid

Peso molecular: 381.37

Ref: 4Z-C-035

Celecoxib

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: (Titration) 98.0 - 102.0 % (dried basis)

Cor e Forma: White or almost white powder

Peso molecular: 381.37

Ref: 7W-GP8233

Celecoxib

CAS: 169590-42-5

Celecoxib

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: >98%

Peso molecular: 381.37

Ref: 54-PC109244

Celecoxib

CAS: 169590-42-5

Celecoxib

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: ≥98%

Peso molecular: 381.37

Ref: 54-BUP15111

Celecoxib-d7 (tolyl-d7)

CAS: 169590-42-5, 544686-21-7

Pureza: 99 atom % D

Cor e Forma: Off White To Yellow Solid

Peso molecular: 388.41

Ref: 3U-D7317

Celecoxib

Produto Controlado

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Cor e Forma: White

Peso molecular: 381.37

Ref: 86-MM0344.00

Celecoxib

Produto Controlado

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Cor e Forma: White

Peso molecular: 381.37

Ref: 04-C11066500

Celecoxib 1.0 mg/ml in Acetonitrile

CAS: 169590-42-5

Cor e Forma: Single Solution

Ref: 61-AMP0344.00-11

Celecoxib RS

CAS: 169590-42-5

Cor e Forma: White

Ref: 2K-107670002

Celecoxib

CAS: 169590-42-5

Fórmula: C₁₇H₁₄F₃N₃O₂S

Peso molecular: 381.37

Ref: ST-EA-CP-C13000

Celecoxib

Produto Controlado

CAS: 169590-42-5

Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),

Fórmula: C₁₇H₁₄F₃N₃O₂S

Cor e Forma: Neat

Peso molecular: 381.37

Ref: TR-C251000

Celecoxib - Bio-X ™

Produto Controlado

CAS: 169590-42-5

Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.
Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 381.37 g/mol

Ref: 3D-BC164295

Celecoxib

Produto Controlado

CAS: 169590-42-5

Celecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib-BioX TM also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.

Fórmula: C₁₇H₁₄F₃N₃O₂S

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 381.37 g/mol

Ref: 3D-FC11300

Celecoxib

CAS: 169590-42-5

Ref: BE-RMCC159000

Celecoxib in Acetonitrile

CAS: 169590-42-5

Acetonitrile

Ref: BE-BePure-21665XA-100