CAS 177582-21-7

Fmoc-Cys(Mmt)-OH

Descrição:

Fmoc-Cys(Mmt)-OH, também conhecido como cisteína protegida por Fmoc com um grupo protetor de metoxitriptil (Mmt), é um composto químico comumente utilizado na síntese de peptídeos. Apresenta um grupo fenilmetoxicarbonilo (Fmoc), que serve como um grupo protetor para o grupo amino da cisteína, permitindo reações seletivas durante a montagem de peptídeos. O grupo Mmt protege a cadeia lateral tiol da cisteína, evitando reações indesejadas enquanto facilita a síntese de peptídeos que contêm este aminoácido. Este composto é tipicamente utilizado na síntese de peptídeos em fase sólida (SPPS) devido à sua estabilidade e compatibilidade com vários reagentes de acoplamento. Fmoc-Cys(Mmt)-OH é caracterizado por sua capacidade de sofrer desproteção em condições ácidas suaves, liberando o resíduo de cisteína livre para reações posteriores. A presença dos grupos Fmoc e Mmt permite um maior controle sobre o processo de síntese, tornando-o um intermediário valioso na produção de peptídeos e proteínas para aplicações de pesquisa e terapêuticas. Seu número CAS, 177582-21-7, é um identificador único que ajuda na catalogação e recuperação de informações relacionadas a este composto específico.

Fórmula: C₃₈H₃₃NO₅S

InChI: InChI=1/C38H33NO5S/c1-43-29-22-20-28(21-23-29)38(26-12-4-2-5-13-26,27-14-6-3-7-15-27)45-25-35(36(40)41)39-37(42)44-24-34-32-18-10-8-16-30(32)31-17-9-11-19-33(31)34/h2-23,34-35H,24-25H2,1H3,(H,39,42)(H,40,41)/t35-/m0/s1

Chave InChI: LOBUWFUSGOYXQX-DHUJRADRSA-N

SMILES: COc1ccc(cc1)C(c1ccccc1)(c1ccccc1)SC[C@@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12

Sinónimos:

• N-alpha-(9-fluorenylmethyloxycarbonyl)-S-p-methoxytrityl-L-cysteine
• (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(4-methoxyphenyl)-diphenyl-methyl]sulfanyl-propanoic acid
• N-ALPHA-FMOC-S-4-METHOXYTRITYL-L-CYSTEINE
• Fmoc-Cys(MMT)-OH(non-animal)
• Fmoc-Cys(4-methoxytrityl)-OH >=98% (HPLC)
• (9H-Fluoren-9-yl)MethOxy]Carbonyl Cys(MMt)-OH
• Fmoc-S-4-methoxytrityl-L-cysteine≥ 99.8% (HPLC, Chiral purity)
• Fmoc-Cys(Mmt)-OH Novabiochem
• (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((4-methoxyphenyl)diphenylmethylthio)propanoic acid
• L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-
• (R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[(4-methoxyphenyl)diphenylmethylsulfanyl]propionic acid
• FMOC-CYS(MMT)-OH USP/EP/BP
• (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[(4-methoxyphenyl)diphenylmethyl]sulfanyl}propanoic acid
• FMOC-L-CYS(MMT)-OH
• FMOC-S-4-METHOXYTRITYL-L-CYSTEINE
• FMOC-CYS(MEOTRT)-OH
• FMOC-S-P-METHOXYTRITYL-L-CYSTEINE
• N-ALPHA-FMOC-S-P-METHOXYTRITYL-L-CYSTEINE
• Nα-(9-Fluorenylmethyloxycarbonyl)-S-4-methoxytrityl-L-cysteine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-cysteine
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-S-P-METHOXYTRITYL-L-CYSTEINE
• NALPHA-9-Fluorenylmethoxycarbonyl-S-(4-methoxytriphenylmethyl)-L-cysteine
• FMoc-Cys(MMt)-OH FMoc-S-p-Methoxytrityl-L-cysteine

Fmoc-Cys(4-methoxytrityl)-OH

CAS: 177582-21-7

4-Methoxytrityl (Mmt) is a very acid-sensitive cysteine protecting group that can selectively be removed by 0.5-1.0% TFA in the presence of scavengers, e.g. TES. Protecting groups of the t-butyl type and S-Trt are left intact under these conditions. Cleavage and cyclization can be achieved concomitantly by adding iodine. It can be used in the solid-phase synthesis of cysteine-containing peptides, and further to selectively deprotect a thiol function in order to introduce a labeling group. Rijkers et al. employed p-methoxytrityl protection for obtaining S-palmitoylated peptides on-resin. The high acid lability of Cys(Mmt) was exploited by Roberts et al. to obtain a library of thioether-linked cyclic peptides. Arendt et al. employed Cys(Mmt) for the synthesis of peptides containing cysteic acid by selective deblocking and oxidation of the thiol moiety with performic acid. Mmt is fully stable to HOBt.

Fórmula: C₃₈H₃₃NO₅S

Pureza: 99.1%

Cor e Forma: White

Peso molecular: 615.76

Ref: 01-4025726

N-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-S-[(4-Methoxyphenyl)Diphenylmethyl]-L-Cysteine

CAS: 177582-21-7

N-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-S-[(4-Methoxyphenyl)Diphenylmethyl]-L-Cysteine

Fórmula: C₃₈H₃₃NO₅S

Pureza: 98%

Peso molecular: 615.74

Ref: 54-OR1029757

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-cysteine

CAS: 177582-21-7

Fórmula: C₃₈H₃₃NO₅S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 615.7373

Ref: IN-DA003QMX

Fmoc-Cys(4-methoxytrityl)-OH

CAS: 177582-21-7

Fórmula: C₃₈H₃₃NO₅S

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White powder

Peso molecular: 615.7

Ref: 7W-GM0099

Fmoc-Cys(MMt)-OH

CAS: 177582-21-7

Fmoc-Cys(MMt)-OH

Fórmula: C₃₈H₃₃NO₅S

Pureza: 98% contains ~ca.11% dioxane

Peso molecular: 615.74

Ref: IN-DG32325

Fmoc-S-4-methoxytrityl-L-cysteine

CAS: 177582-21-7

Fmoc-S-4-methoxytrityl-L-cysteine is a synthetic, amphipathic, amide, ester linkages, cyclic peptide. It has been shown to be a potent growth factor that inhibits the proliferation of human pancreatic cancer cells in tissue culture and induces apoptosis in these cells. Fmoc-S-4-methoxytrityl-L-cysteine also inhibits the growth of staphylococcus in tissue culture and reduces metastatic pancreatic cancer cell proliferation in rats.

Fórmula: C₃₈H₃₃NO₅S

Pureza: 90%Min

Cor e Forma: White Powder

Peso molecular: 615.74 g/mol

Ref: 3D-FF47756

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-cysteine

CAS: 177582-21-7

Pureza: 95% contains ~ca.11% dioxane

Cor e Forma: Solid

Peso molecular: 615.7399902

Ref: 10-F601172