CAS 179324-69-7

Bortezomibe

Descrição:

Bortezomibe é um inibidor do proteassoma utilizado principalmente no tratamento do mieloma múltiplo e certos tipos de linfoma. É um composto sintético que pertence à classe dos derivados do ácido bórico. A fórmula química de Bortezomibe é C19H25BoroN4O4, e apresenta um átomo de boro que desempenha um papel crucial em seu mecanismo de ação, que envolve a inibição do proteassoma, um complexo celular responsável pela degradação de proteínas ubiquitinadas. Essa inibição leva ao acúmulo de fatores pró-apoptóticos e reguladores do ciclo celular, induzindo, em última análise, a apoptose em células cancerosas. Bortezomibe é administrado por injeção intravenosa ou subcutânea e é conhecido por seus efeitos colaterais, que podem incluir neuropatia periférica, problemas gastrointestinais e toxicidades hematológicas. Sua farmacocinética envolve rápida absorção e distribuição, com uma meia-vida que permite esquemas de dosagem eficazes. No geral, Bortezomibe representa um avanço significativo na terapia direcionada ao câncer, mostrando o potencial de pequenas moléculas no tratamento de malignidades hematológicas.

Fórmula: C₁₉H₂₅BN₄O₄

InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

Chave InChI: InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC(C)C)B(O)O)=O)NC(=O)C=2C=NC=CN2

Sinónimos:

• B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
• Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [3-methyl-1-[[1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-, [S-(R*,S*)]-
• Bortezomib for research
• Bortizomib
• Brotezamide
• Dpba
• Ldp 341
• Mg 341
• Mln 341
• N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
• N-[(1S)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-D-phenylalaninamide
• NSC 681239
• PS 341 (pharmaceutical)
• Ps 314
• Ps 341
• Radiciol
• Velcade

Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 384.24

Ref: 3B-B5741

Bortezomib, 98%

CAS: 179324-69-7

Bortezomib, 179324-69-7, is a peptidic boronic acid analog and antineoplastic agent which turns off cell signaling pathways through 26S proteasome inhibition. Learn more.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98%

Cor e Forma: White to off-white, Powder or crystals or crystalline powder

Peso molecular: 384.24

Ref: 02-J60378

Bortezomib

CAS: 179324-69-7

((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98%

Peso molecular: 384.24

Ref: IN-DG106087

Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 384.2372

Ref: IN-DA0026XG

Bortezomib

CAS: 179324-69-7

Bortezomib

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 98% (nmr) (Typical Value in Batch COA)

Cor e Forma: Solid

Peso molecular: 384.23719

Ref: 54-BISN0125

Bortezomib

CAS: 179324-69-7

Bortezomib

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: ≥95%

Peso molecular: 384.24

Ref: 54-BUP15505

Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder or solid

Peso molecular: 384.24

Ref: 7W-GP0262

Bortezomib [Optimized for Cell Culture]

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 384.24

Ref: 3B-B6775

Bortezomib

CAS: 179324-69-7

Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: 97.79% - >99.99%

Cor e Forma: White Solid

Peso molecular: 384.24

Ref: TM-T2399

(1R,2S)-Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Peso molecular: 384.24

Ref: 4Z-B-4697

Bortezomib

CAS: 179324-69-7

Fórmula: C₁₉H₂₅BN₄O₄

Peso molecular: 384.24

Ref: ST-EA-CP-B34000

Bortezomib

Produto Controlado

CAS: 179324-69-7

Stability Hygroscopic and Moisture Sensitive
Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);

Fórmula: C₁₉H₂₅BN₄O₄

Cor e Forma: Neat

Peso molecular: 384.24

Ref: TR-B675700

Bortezomib-D8 (Major)

Produto Controlado

CAS: 179324-69-7

Applications Labelled Bortezomib, which the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.d6-3%d7-10%d8-86%
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)

Fórmula: C₁₉H₁₇D₈BN₄O₄

Cor e Forma: Neat

Peso molecular: 392.29

Ref: TR-B675702

Bortezomib

CAS: 179324-69-7

Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 384.24 g/mol

Ref: 3D-FM19000

Bortezomib - Bio-X ™

CAS: 179324-69-7

Bortezomib is a selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating t-cell lymphomas and multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.

Fórmula: C₁₉H₂₅BN₄O₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 384.24 g/mol

Ref: 3D-BB164258

Bortezomib

CAS: 179324-69-7

Pureza: 98%

Peso molecular: 384.24

Ref: 10-M06307