CAS 1801896-05-8

Fórmula: C18H15F2IN2O5

InChI: InChI=1S/C18H15F2IN2O5/c19-13-6-10(21)1-2-14(13)22-16-12(18(26)23-28-11(7-24)8-25)5-9-3-4-27-17(9)15(16)20/h1-6,11,22,24-25H,7-8H2,(H,23,26)

Chave InChI: VUJYNHRRRJUAHQ-UHFFFAOYSA-N

SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=C3C=COC3=C2F)C(=O)NOC(CO)CO

N-((1,3-Dihydroxypropan-2-yl)oxy)-7-fluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-5-carboxamide

CAS: 1801896-05-8

N-((1,3-Dihydroxypropan-2-yl)oxy)-7-fluoro-6-(2-fluoro-4-iodophenyl)amino)benzofuran-5 -carboxamide (BX795) is a potent and selective inhibitor of the immune checkpoint protein PD1, which is expressed on T cells. This drug binds to the extracellular domain of PD1 and blocks its interaction with the ligands PDL1 and PDL2. BX795 inhibits the activation of T cells by blocking the signal transduction pathway induced by PD1 binding to its ligands. This drug has been shown to have an excellent safety profile in preclinical studies and will be tested in clinical trials for cancer immunotherapy.

Fórmula: C₁₈H₁₅F₂IN₂O₅

Pureza: Min. 95%

Peso molecular: 504.2 g/mol

Ref: 3D-BXC89605

EBI-1051

CAS: 1801896-05-8

EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).

Fórmula: C₁₈H₁₅F₂IN₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 504.22

Ref: TM-T15193