CAS 1860875-51-9
:Fórmula:C22H18ClF2N3O4
InChI:InChI=1S/C22H18ClF2N3O4/c23-15-4-2-14(3-5-15)22(24,25)21(32)26-10-12-1-6-16-13(9-12)11-28(20(16)31)17-7-8-18(29)27-19(17)30/h1-6,9,17H,7-8,10-11H2,(H,26,32)(H,27,29,30)
Chave InChI:PWBHUSLMHZLGRN-UHFFFAOYSA-N
SMILES:C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)CNC(=O)C(C4=CC=C(C=C4)Cl)(F)F
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Foram encontrados 6 produtos.
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Eragidomide
CAS:Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.Fórmula:C22H18ClF2N3O4Pureza:99.13% - 99.63%Cor e Forma:White SolidPeso molecular:461.852-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CAS:2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamideFórmula:C22H18ClF2N3O4Pureza:98%Peso molecular:461.85Cereblon modulator 1
CAS:Cereblon modulator 1 is a prodrug that binds to the E3 ubiquitin ligase, Cereblon, and blocks its activity. This drug is being studied for use in hematologic malignancies. Cereblon modulator 1 has been shown to inhibit the proliferation of myelodysplastic cells by inducing c-myc protein degradation and inhibiting IL-1 receptor activation. The drug also inhibits the growth of cancer cells by blocking the Tautomerase function of Cereblon, thereby preventing the conversion of inactive proteins into active proteins. Cereblon modulator 1's linker is heterocyclic, which is likely responsible for its antagonist effect on IL-1 receptor activation.
Fórmula:C22H18ClF2N3O4Pureza:Min. 95%Peso molecular:461.8 g/mol2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CAS:Fórmula:C22H18ClF2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:461.8458
