CAS 19210-12-9
:Harpagosídeo
Descrição:
Harpagosídeo é um glicosídeo iridoide que ocorre naturalmente, encontrado principalmente nas raízes da planta Harpagophytum procumbens, comumente conhecida como unha do diabo. É caracterizado por sua fórmula molecular, que inclui átomos de carbono, hidrogênio e oxigênio, refletindo sua estrutura glicosídica. Harpagosídeo é conhecido por suas potenciais propriedades anti-inflamatórias e analgésicas, tornando-o de interesse na medicina herbal e em suplementos dietéticos, particularmente para condições como artrite e dor nas articulações. O composto exibe um sabor amargo e é frequentemente extraído para uso em várias formulações. Em termos de solubilidade, Harpagosídeo é geralmente solúvel em água e solventes orgânicos, o que facilita sua extração e incorporação em vários produtos. Seus efeitos farmacológicos são atribuídos à sua capacidade de modular vias inflamatórias e influenciar a percepção da dor. Assim como muitos compostos naturais, a eficácia e segurança de Harpagosídeo podem variar com base na dosagem e na resposta individual, necessitando de mais pesquisas para entender completamente seu potencial terapêutico e mecanismos de ação.
Fórmula:C24H30O11
InChI:InChI=1S/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1
Chave InChI:InChIKey=KVRQGMOSZKPBNS-FMHLWDFHSA-N
SMILES:O[C@@]12[C@@]([C@](OC(/C=C/C3=CC=CC=C3)=O)(C)C[C@H]1O)([C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)OC=C2)[H]
Sinónimos:- (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
- (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl (2E)-3-phenylprop-2-enoate
- (1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside
- 1-(Hexopyranosyloxy)-4A,5-Dihydroxy-7-Methyl-1,4A,5,6,7,7A-Hexahydrocyclopenta[C]Pyran-7-Yl 3-Phenylprop-2-Enoate
- E-Harpagoside
- Hapagoside
- Harpagoside
- β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
- β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1-yl
- β-<span class="text-smallcaps">D</span>-Glucopyranoside, 1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(1-oxo-3-phenyl-2-propenyl)oxy]cyclopenta[c]pyran-1-yl, [1S-[1α,4aα,5α,7α(E),7aα]]-
- β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1-yl
- (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-D-glucopyranoside
- β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
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Harpagoside
CAS:Harpagoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.Fórmula:C24H30O11Pureza:(HPLC) ≥98%Cor e Forma:PowderPeso molecular:494.49Harpagoside
CAS:Harpagoside has anti-inflammatory effects, it blocks lipopolysaccharide (LPS)-induced bone loss in an inflammatory osteoporosis model, and it does not prevent ovariectomy-mediated bone erosion in a postmenopausal osteoporosis model, it may lead to a partial prevention of obesity-induced atherosclerosis by attenuating inflammatory responses. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. Harpagoside exerts neuroprotection effect and ameliorates learning and memory deficit appears to be associated, at least in part, with up-regulation of brain-derived neurotrophic factor (BDNF) content as well as activating its downstream signaling pathways, e.g., MAPK/PI3K pathways.Fórmula:C24H30O11Pureza:95%~99%Peso molecular:494.493Harpagoside
CAS:Fórmula:C24H30O11Pureza:>95.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:494.49Harpagoside (Standard)
CAS:Harpagoside (Standard) is a reference standard for research and analysis in studies involving Harpagoside. 1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression of cyclooxygenase-2 and inducible nitric oxide in HepG2 cells.Fórmula:C24H30O11Peso molecular:494.49Harpagoside
CAS:(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamateFórmula:C24H30O11Pureza:99%Peso molecular:494.49Harpagoside
CAS:Harpagoside: anti-inflammatory; 3 mM inhibits seed germination; reduces COX-2, iNOS mRNA, and protein in HepG2.Fórmula:C24H30O11Pureza:99.71% - ≥95%Cor e Forma:White SolidPeso molecular:494.49Harpagoside
CAS:Natural glycosideFórmula:C24H30O11Pureza:≥ 95.0 % (HPLC)Cor e Forma:PowderPeso molecular:494.5Harpagoside
CAS:Applications Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.
References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);Fórmula:C24H30O11Cor e Forma:NeatPeso molecular:494.49Harpagoside
CAS:Harpagoside is a bioactive compound, which is an iridoid glycoside derived from the root of the plant Harpagophytum procumbens, commonly known as Devil’s Claw. This compound is predominantly sourced from Southern Africa, where the plant is native to semi-arid regions and has been traditionally used in herbal medicine.Fórmula:C24H30O11Pureza:Min. 95%Cor e Forma:PowderPeso molecular:494.5 g/molHarpagoside-D5
CAS:Produto ControladoApplications Harpagoside-D5 is an isotope labelled analog of Harpagoside (H105275). Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.
References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);Fórmula:C24D5H25O11Cor e Forma:NeatPeso molecular:499.519
