CAS 20736-09-8

saikosaponina a

Descrição:

saikosaponina a é uma saponina triterpenoide derivada principalmente das raízes da planta Bupleurum falcatum, que é comumente usada na medicina tradicional. É caracterizada por sua estrutura complexa, apresentando uma espinha dorsal semelhante a um esteroide com múltiplos moieties de açúcar anexados, o que contribui à sua atividade biológica. saikosaponina a exibe uma variedade de propriedades farmacológicas, incluindo efeitos anti-inflamatórios, hepatoprotetores e imunomoduladores. Foi estudado por suas potenciais aplicações terapêuticas em várias condições, incluindo doenças hepáticas e câncer. Sabe-se que o composto interage com as membranas celulares e pode influenciar as vias de sinalização celular, o que pode estar na base de seus diversos efeitos biológicos. Além disso, saikosaponina a mostrou potencial para aumentar a eficácia de certos agentes quimioterápicos. No entanto, sua biodisponibilidade e metabolismo no corpo humano são áreas de pesquisa em andamento, pois podem afetar significativamente seu potencial terapêutico. No geral, saikosaponina a representa um produto natural promissor com um interesse farmacológico significativo.

Fórmula: C₄₂H₆₈O₁₃

InChI: InChI=1/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26+,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1

Chave InChI: InChIKey=KYWSCMDFVARMPN-FMIBPMOUSA-N

SMILES: C[C@]12[C@@]3(C4([C@@](CO3)([C@@H](O)C1)CCC(C)(C)C4)[H])C=C[C@]5([C@@]2(C)CC[C@@]6([C@]5(C)CC[C@H](O[C@H]7[C@H](O)[C@@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@@H](C)O7)[C@]6(CO)C)[H])[H]

Sinónimos:

• (3Beta,4Alpha,16Beta)-13,28-Epoxy-16,23-Dihydroxyolean-11-En-3-Yl-6-Deoxy-3-O-Beta-D-Glucopyranosyl-Beta-D-Galactopyranoside
• (3beta,13alpha,16beta,17alpha)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside
• (3β,4α,16β)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-galactopyranoside
• Oleanane, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Salikosaponin A
• sailkosaponin A
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-<smallcap>D</span>-glucopyranosyl-
• (3β,4α,16β)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
• β-D-Galactopyranoside, (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-
• Oleanane, β-D-galactopyranoside deriv.
• Saikosaponin A
• Thesaikosaponin A
• [(3β,4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
• SAIKOSAPONIN A(RG)
• SABINYL ACETATE(RG)
• β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23-
• Saikosaponin A, 98%, from Bupleurum chinense DC.
• SAILKOSAPONINS A
• dihydroxyolean-11-en-3-yl6-deoxy-3-O-β-D-
• [(4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
• Saikosaponin a std.

Saikosaponin A

CAS: 20736-09-8

Fórmula: C₄₂H₆₈O₁₃

Pureza: >95.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 780.99

Ref: 3B-A3408

SAIKOSAPONIN A CRS

CAS: 20736-09-8

SAIKOSAPONIN A CRS

Ref: 41-Y0001932

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A

Fórmula: C₄₂H₆₈O₁₃

Pureza: 99.5%

Peso molecular: 780.98

Ref: 54-BUP02763

Saikosaponin A

CAS: 20736-09-8

Fórmula: C₄₂H₆₈O₁₃

Peso molecular: 780.98

Ref: 7W-GC0592

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A (SSa), a main constituent of the Chinese herb Bupleurum chinense DC, has antiepileptic activity,could inhibit NMDA receptor current and persistent sodium current, and inhibit epileptiform discharges induced by 4AP in a dose-dependent manner.

Fórmula: C₄₂H₆₈O₁₃

Pureza: 95%~99%

Cor e Forma: Powder

Peso molecular: 780.993

Ref: BP-BP1238

Saikosaponin A (Standard)

CAS: 20736-09-8

Saikosaponin A (Standard) is a reference standard for research and analysis in studies involving Saikosaponin A. Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

Fórmula: C₄₂H₆₈O₁₃

Cor e Forma: Solid

Peso molecular: 780.9815

Ref: TM-TMSM-0961

Saikosaponin A

CAS: 20736-09-8

Fórmula: C₄₂H₆₈O₁₃

Pureza: 95.0%

Cor e Forma: Solid

Peso molecular: 780.9815

Ref: IN-DA002J0O

Saikosaponin A

Produto Controlado

CAS: 20736-09-8

Stability Hygroscopic
Applications Saikosaponin A was shown to exhibit anti-inflammatory activities by suppressing activation of NF-kB signaling pathway.
References Wu, S.J., et al.: Am. J. Chin. Med., 38, 99 (2010); Wu. S.J., et al.: J. Med. Food., 11, 224 (2008); Yoon, S.S., et al.: Neurosci. Lett., 529, 97 (2012); Lu, C.N., et al.: Int. Immunopharmacol., 14, 121 (2012);

Fórmula: C₄₂H₆₈O₁₃

Cor e Forma: Neat

Peso molecular: 780.98

Ref: TR-S083900

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-

Fórmula: C₄₂H₆₈O₁₃

Pureza: 99.57% - 99.88%

Cor e Forma: White Solid

Peso molecular: 780.9815

Ref: TM-T2768

Saikosaponin A

CAS: 20736-09-8

Natural glycoside

Fórmula: C₄₂H₆₈O₁₃

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 781

Ref: 5G-89526

Saikosaponin A

CAS: 20736-09-8

Saikosaponin A is a triterpene saponin, which is a bioactive compound extracted from the roots of the Bupleurum species, primarily Bupleurum falcatum. As a phytochemical, it interacts with cell membranes to exert its effects. Saikosaponin A is known to modulate inflammatory pathways by inhibiting the production of pro-inflammatory cytokines and influencing the NF-κB signaling pathway. Additionally, it can enhance immune responses by regulating T-cell proliferation and differentiation.

Fórmula: C₄₂H₆₈O₁₃

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 780.98 g/mol

Ref: 3D-OS09826

Saikosaponin a

CAS: 20736-09-8

Fórmula: C₄₂H₆₈O₁₃

Peso molecular: 781.0

Ref: BE-RMT10740