CAS 208538-73-2

Sódio de Micafungina

Descrição:

Sódio de Micafungina é um agente antifúngico pertencente à classe das equinocandinas, utilizado principalmente no tratamento de infecções fúngicas invasivas, particularmente aquelas causadas por espécies de Candida e Aspergillus. Funciona inibindo a síntese de β-(1,3)-D-glucano, um componente essencial da parede celular fúngica, comprometendo assim a integridade estrutural do fungo e levando à lise celular. A micafungina é tipicamente administrada por via intravenosa e é caracterizada por sua atividade de amplo espectro contra vários patógenos fúngicos, tornando-se uma opção valiosa em ambientes clínicos, especialmente para pacientes imunocomprometidos. A substância é solúvel em água e apresenta estabilidade em condições fisiológicas. Sua farmacocinética envolve uma meia-vida relativamente longa, permitindo a dosagem uma vez ao dia. Efeitos colaterais comuns podem incluir reações relacionadas à infusão, elevações de enzimas hepáticas e distúrbios gastrointestinais. Devido ao seu mecanismo de ação e perfil de segurança, a micafungina é frequentemente preferida em casos onde outras terapias antifúngicas podem ser menos eficazes ou contraindicadas.

InChI: InChI=1/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26-,31+,34?,35-,37+,38+,42-,43-,44-,45-,46-,47+,48?,52-;/m1./s1

SMILES: CCCCCOc1ccc(cc1)c1cc(c2ccc(cc2)C(=O)NC2CC(C(N=C(C3C(C(C)CN3C(=O)C(C(CC(=N)O)O)N=C(C(C(C(c3ccc(c(c3)OS(=O)(=O)O)O)O)O)N=C(C3CC(CN3C(=O)C(C(C)O)N=C2O)O)O)O)O)O)O)O)no1.[Na]

Sinónimos:

• Fk 463
• 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((1R)-3-Amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((1R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-((4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoyl)amino)tetracosahydro-1H-dipyrrolo(2,1-c:2',1'-l)(1,4,7,10,13,16)hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sodium sulfate
• Fk463
• Unii-Is1Up79R56
• Pneumocandin A0, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(5-(5-(pentyloxy)phenyl)-3-isoxazolyl)benzoyl)-L-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxy-3-(sulfooxy)phenyl)-L-threonine)-, monosodium salt

Micafungin Sodium

CAS: 208538-73-2

Fórmula: C56H70N9O23SNa

Pureza: ≥97% (HPLC)

Cor e Forma: white to beige powder

Peso molecular: 1292.26

Ref: 23-SML2268

Micafungin Sodium (INTERNATIONAL COLD SHIPMENT REQUIRED)

CAS: 208538-73-2

Antibiotics nesoi

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Cor e Forma: White Powder

Peso molecular: 1291.4203

Ref: 45-1443384

Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1)

CAS: 208538-73-2

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 1292.2563

Ref: IN-DA002JQV

Micafungin Sodium Salt

CAS: 208538-73-2

Fórmula: C₅₆H₇₀N₉O₂₃S·Na

Cor e Forma: White To Off-White Solid Solid

Peso molecular: 1269.29 22.99

Ref: 4Z-PM-127001

Micafungin (sodium)

CAS: 208538-73-2

Micafungin (sodium)

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 1292.273

Ref: 54-OR1031626

Micafungin sodium

CAS: 208538-73-2

Fórmula: C₅₆H₇₁N₉O₂₃S·Na

Pureza: ≥ 98.0% (anhydrous)

Cor e Forma: White to off-white or beige powder

Peso molecular: 1292.28

Ref: 7W-GX5973

Micafungin sodium

CAS: 208538-73-2

Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Pureza: 98% - 99.41%

Cor e Forma: Solid

Peso molecular: 1292.26

Ref: TM-T1794

Micafungin sodium

CAS: 208538-73-2

Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Pureza: 98%

Peso molecular: 1292.26

Ref: IN-DG626393

Micafungin Sodium

CAS: 208538-73-2

Fórmula: C₅₆H₇₀N₉O₂₃SNa

Peso molecular: 1269.3 : 23.0

Ref: ST-EA-CP-M94010

Micafungin Sodium

CAS: 208538-73-2

Stability Hygroscopic
Applications An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.
References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999);

Fórmula: C₅₆H₇₀N₉O₂₃S·Na

Cor e Forma: Neat

Peso molecular: 1292.26

Ref: TR-M342350

Micafungin sodium - Bio-X ™

CAS: 208538-73-2

Micafungin, as one of three echinocandina, has been proven to be a successful antifungal therapeutic in treating general Candida fungus infections. The treatment of immunocompromised patients is particularly important as Candida infections cause high mortality rates in patients in intensive care units, receiving chemotherapy, or stem cell transplants. This product acts as an anti-fungal by inhibiting the 1,3-beta-D-glucan synthase enzyme. As a result the production of 1,3-beta-D-glucan, which is crucial to the fungal cell wall, is hindered. Thus, the fungal cell wall loses integrity allowing for osmotic instability and cell lysis to occur.

Fórmula: C₅₆H₇₁N₉O₂₃S•Na

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,293.27 g/mol

Ref: 3D-BM164667

Micafungin sodium

CAS: 208538-73-2

Anti-fungal; glucan synthase inhibitor

Fórmula: C₅₆H₇₀N₉NaO₂₃S

Pureza: Min. 97 Area-%

Cor e Forma: White Powder

Peso molecular: 1,292.26 g/mol

Ref: 3D-FM34148

Micafungin sodium salt-[13C6]

CAS: 208538-73-2

Ref: BE-MC-7697

Micafungin sodium

CAS: 208538-73-2

Ref: BE-RMCP507001

Micafungin Sodium

CAS: 208538-73-2

Ref: BE-MU-7697

Micafungin sodium

CAS: 208538-73-2

Pureza: 95%

Peso molecular: 1291.42

Ref: 10-F814152

Micafungin-¹³C₆ Sodium

Produto Controlado

CAS: 208538-73-2

Fórmula: C₅₀C₆H₇₀N₉NaO₂₃S

Cor e Forma: Neat

Peso molecular: 1298.22

Ref: TR-M442141

Micafungin-d11 Sodium

Produto Controlado

CAS: 208538-73-2

Applications Micafungin-d11 Sodium is the isotope labelled analog of Micafungin Sodium (M342350); an echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. Micafungin Sodium also represents a valuable treatment option for fungal infections.
References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999)

Fórmula: C₅₆H₅₉D₁₁N₉NaO₂₃S

Cor e Forma: Neat

Peso molecular: 1303.33

Ref: TR-M342352