CAS 2167898-24-8

Fórmula: C23H30N8O

InChI: InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)/i9D2,10D2,11D2,12D2

Chave InChI: RHXHGRAEPCAFML-PMCMNDOISA-N

SMILES: [2H]C1(C(N(C(C(N1)([2H])[2H])([2H])[2H])C2=CN=C(C=C2)NC3=NC=C4C=C(N(C4=N3)C5CCCC5)C(=O)N(C)C)([2H])[2H])[2H]

Ribociclib-D8

CAS: 2167898-24-8

Ribociclib-D8 is the deuterated form of Ribociclib (T6199), also known as LEE011, which acts as a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM. Its activity against the cyclin B/CDK1 complex is over 1000 times weaker.

Fórmula: C₂₃H₃₀N₈O

Peso molecular: 442.59

Ref: TM-TMID-1108