CAS 2183470-09-7

Fórmula: C19H12Cl2F2N4O3S

InChI: InChI=1S/C19H12Cl2F2N4O3S/c20-12-5-11(9-28)17(21)16(6-12)31(29,30)27-15-4-3-14(22)13(18(15)23)2-1-10-7-25-19(24)26-8-10/h3-8,27-28H,9H2,(H2,24,25,26)

Chave InChI: VJXAWOQPYMAEFQ-UHFFFAOYSA-N

SMILES: C1=CC(=C(C(=C1NS(=O)(=O)C2=CC(=CC(=C2Cl)CO)Cl)F)C#CC3=CN=C(N=C3)N)F

GCN2-IN-6

CAS: 2183470-09-7

GCN2-IN-6

Fórmula: C₁₉H₁₂Cl₂F₂N₄O₃S

Pureza: ≥95%

Peso molecular: 485.29

Ref: 54-BUP14401

GCN2-IN-6

CAS: 2183470-09-7

Ref: IN-DA01V4EW

GCN2-IN-6

CAS: 2183470-09-7

GCN2-IN-6 is a potent and selective activator of the GCN2 protein kinase. GCN2 is a serine/threonine protein kinase that phosphorylates eIF2α, leading to an increase in protein synthesis. The GCN2-IN-6 peptide can be used as a research tool to investigate the role of GCN2 in cell biology and for the study of ion channels, peptides and antibodies.
GCN2-IN-6 has been shown to inhibit antibody production by inhibiting protein interactions with B cells and macrophages, which are important for antibody production.

Fórmula: C₁₉H₁₂Cl₂F₂N₄O₃S

Pureza: Min. 95%

Peso molecular: 485.3 g/mol

Ref: 3D-IMD47009

GCN2-IN-6

CAS: 2183470-09-7

GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).

Fórmula: C₁₉H₁₂Cl₂F₂N₄O₃S

Pureza: 95.04% - 98.72%

Cor e Forma: Yellow Solid

Peso molecular: 485.29

Ref: TM-T11374