CAS 2460722-04-5

Fórmula: C23H25F5N2O4S

InChI: InChI=1S/C23H25F5N2O4S/c1-4-35(33,34)29-20-18(30(12-23(20,27)28)21(31)22(2,3)32)10-13-6-5-7-17(19(13)26)14-8-15(24)11-16(25)9-14/h5-9,11,18,20,29,32H,4,10,12H2,1-3H3/t18-,20+/m0/s1

Chave InChI: KVMGAIOTUIGROS-AZUAARDMSA-N

SMILES: CCS(=O)(=O)N[C@@H]1[C@@H](N(CC1(F)F)C(=O)C(C)(C)O)CC2=C(C(=CC=C2)C3=CC(=CC(=C3)F)F)F

Oveporexton

CAS: 2460722-04-5

Oveporexton (TAK-861) is an orally active selective orexin type 2 receptor (OX2R) agonist that can activate recombinant OX2R with an EC₅₀ of 2.5 nM, showing approximately 3000-fold selectivity over OX1R (EC₅₀=7500 nM). In mouse tuberomammillary nucleus histaminergic neurons, Oveporexton can cause dose-dependent depolarization with an EC₅₀ of 31.7 nM, and can increase wakefulness after oral administration in mouse and cynomolgus monkey models. Oveporexton can be used in pharmacological mechanism research on orexin OX2R signaling, arousal state regulation, and sleepiness-related animal models.

Fórmula: C₂₃H₂₅F₅N₂O₄S

Pureza: 99.76%

Peso molecular: 520.51

Ref: TM-T200854

N-[(2S,3R)-4,4-Difluoro-1-(2-hydroxy-2-methyl-1-oxopropyl)-2-[(2,3′,5′-trifluoro[1,1′-biphenyl]-3-yl)methyl]-3-pyrrolidinyl]ethanesulfonamide

CAS: 2460722-04-5

Fórmula: C₂₃H₂₅F₅N₂O₄S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 520.5126

Ref: IN-DA0EXPCH