CAS 247062-33-5

abaloparatida

Descrição:

abaloparatida é um peptídeo sintético que funciona como um análogo do peptídeo relacionado à hormona paratireoide (PTHrP). É utilizado principalmente no tratamento da osteoporose, particularmente em mulheres na pós-menopausa com alto risco de fraturas. A substância promove a formação óssea ao estimular a atividade dos osteoblastos e aumentar a absorção de cálcio nos intestinos. abaloparatida é caracterizado por sua sequência específica de aminoácidos, que imita a ação da hormona paratireoide natural, levando a um aumento da densidade mineral óssea. É administrado por injeção subcutânea e tem uma meia-vida relativamente curta, necessitando de doses diárias. O composto é conhecido por seu potencial de reduzir o risco de fraturas vertebrais e não vertebrais, tornando-se uma opção terapêutica valiosa no manejo da osteoporose. Além disso, seu perfil de segurança inclui efeitos colaterais comuns, como náuseas, tontura e reações no local da injeção. No geral, abaloparatida representa um avanço significativo no tratamento da osteoporose, oferecendo uma abordagem direcionada para melhorar a saúde óssea.

Fórmula: C174H300N56O49

InChI: InChI=1S/C174H300N56O49/c1-26-93(20)136(228-165(274)126(80-232)224-141(250)101(39-28-32-56-176)200-129(236)78-195-140(249)100(38-27-31-55-175)201-161(270)123(73-133(243)244)223-160(269)121(71-98-76-190-82-197-98)220-158(267)118(68-90(14)15)216-155(264)114(64-86(6)7)213-148(257)107(45-50-127(180)234)207-159(268)120(70-97-75-189-81-196-97)219-151(260)111(49-54-132(241)242)209-164(273)125(79-231)225-167(276)135(92(18)19)227-139(248)94(21)179)168(277)210-108(46-51-128(181)235)149(258)222-124(74-134(245)246)162(271)217-112(62-84(2)3)152(261)205-105(44-37-61-194-173(187)188)143(252)203-103(42-35-59-192-171(183)184)142(251)204-104(43-36-60-193-172(185)186)144(253)206-110(48-53-131(239)240)150(259)214-115(65-87(8)9)154(263)215-113(63-85(4)5)153(262)208-109(47-52-130(237)238)147(256)202-102(40-29-33-57-177)145(254)211-116(66-88(10)11)156(265)218-119(69-91(16)17)166(275)230-174(24,25)170(279)226-106(41-30-34-58-178)146(255)212-117(67-89(12)13)157(266)221-122(72-99-77-191-83-198-99)163(272)229-137(96(23)233)169(278)199-95(22)138(182)247/h75-77,81-96,100-126,135-137,231-233H,26-74,78-80,175-179H2,1-25H3,(H2,180,234)(H2,181,235)(H2,182,247)(H,189,196)(H,190,197)(H,191,198)(H,195,249)(H,199,278)(H,200,236)(H,201,270)(H,202,256)(H,203,252)(H,204,251)(H,205,261)(H,206,253)(H,207,268)(H,208,262)(H,209,273)(H,210,277)(H,211,254)(H,212,255)(H,213,257)(H,214,259)(H,215,263)(H,216,264)(H,217,271)(H,218,265)(H,219,260)(H,220,267)(H,221,266)(H,222,258)(H,223,269)(H,224,250)(H,225,276)(H,226,279)(H,227,248)(H,228,274)(H,229,272)(H,230,275)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t93-,94-,95-,96+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,135-,136-,137-/m0/s1

Chave InChI: BVISQZFBLRSESR-XSCWXTNMSA-N

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)N

Abaloparatide

CAS: 247062-33-5

The pTHrP-analog abaloparatide (BIM-44058) promoting bone growth has been developed for the treatment of osteoporosis.

Fórmula: C₁₇₄H₃₀₀N₅₆O₄₉

Pureza: 96.2%

Cor e Forma: White Whitish Powder

Peso molecular: 3960.64

Ref: 01-4105586

Abaloparatide

CAS: 247062-33-5

Abaloparatide (BA 058) is a selective PTHR1 analog that promotes bone growth and may be researched for osteoporosis.

Fórmula: C₁₇₄H₃₀₀N₅₆O₄₉

Cor e Forma: Solid

Peso molecular: 3960.5896

Ref: TM-T73690

Abaloparatide

CAS: 247062-33-5

Fórmula: C₁₇₆H₃₀₄N₅₆O₅₁

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 4020.6416

Ref: IN-DA01FW1Z

Abaloparatide

CAS: 247062-33-5

Fórmula: C₁₇₄H₃₀₀N₅₆O₄₉·C₂H₄O₂

Peso molecular: 3960.66 60.05

Ref: 4Z-PA-421001

Abaloparatide acetate

CAS: 247062-33-5

Abaloparatide acetate is a peptide hormone that belongs to the calcitonin family. It is an analog of human calcitonin, which is a hormone that regulates bone metabolism. Abaloparatide acetate has been shown to have long-term efficacy and potency in humans as well as in vitro methods. It also has favorable pharmacokinetics and can be administered by subcutaneous injection. Clinical studies have shown that abaloparatide acetate can reduce the rate of bone loss, increase bone mineral density, and reduce the risk of fractures in postmenopausal women with osteoporosis. The drug's mechanism of action is not fully understood, but it may act by inhibiting the formation of osteoclasts or increasing their apoptosis, which would result in decreased resorption of bone tissue.

Fórmula: C₁₇₄H₃₀₀N₅₆O₄₉

Pureza: Min. 95%

Peso molecular: 3,961 g/mol

Ref: 3D-XJA06233

Abaloparatide

CAS: 247062-33-5

Ref: ST-EA-CP-A352000