CAS 25126-32-3

(27-tir(so(3)H))colecistoquinina-fragmento (26-33)-amida

Descrição:

A substância química conhecida como "(27-tir(so(3)H))colecistoquinina-fragmento (26-33)-amida," com o número CAS 25126-32-3, é um fragmento peptídico derivado da colecistoquinina (CCK), um hormônio envolvido na digestão e saciedade. Este fragmento específico consiste em aminoácidos de 26 a 33 da molécula de CCK, com uma tirosina sulfatada na posição 27, que é crucial para sua atividade biológica. A presença do grupo sulfato melhora a interação do peptídeo com seus receptores, influenciando vários processos fisiológicos, como a contração da vesícula biliar e a secreção de enzimas do pâncreas. A estrutura deste peptídeo inclui uma sequência de aminoácidos ligados por ligações peptídicas, e exibe propriedades típicas de peptídeos, como solubilidade em água e estabilidade em condições fisiológicas. Sua importância biológica é sublinhada por seu papel no sistema gastrointestinal, tornando-o um assunto de interesse em estudos relacionados à digestão, regulação do apetite e potenciais aplicações terapêuticas em distúrbios gastrointestinais.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

InChI: InChI=1/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

SMILES: CSCC[C@@H](C(=NCC(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=O)O)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)OS(=O)(=O)O)N=C([C@H](CC(=O)O)N)O)O

Sinónimos:

• (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
• Sincalide
• Cholecystokinin Octapeptide
• Tyr(SO3H]27)Cholecystokinin fragment 26-33 Amide
• alpha-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-alpha-aspartylphenylalaninamide
• L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
• Sincalide(CCK-8)
• Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
• Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
• Cholecystokinin C-terminal octapeptide
• Cholecystokinin octapeptide (26-33 sulfated)
• Cholecystokinin-(26-33)-amide
• Cholecystokinin-8 (chicken)
• Cholecystokinin-8 (pig)
• Cholecystokinin-8 (Squalus acanthias)
• Cholecystokinin-8 (swine)
• Cholecystokinin-pancreozymin (swine intestine C-terminal octapeptide)
• Cholecystokinin-pancreozymin C-terminal octapeptide
• Human CCK-8
• L-Phenylalaninamide, L-α-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• Sincalid
• Sincalida

Cholecystokinin, CCK Octapeptide (26-33)

CAS: 25126-32-3

For cellular and molecular biology applications

Cor e Forma: White, Lyophilized Powder

Ref: 02-J66669

Cholecystokinin Octapeptide (sulfated)

CAS: 25126-32-3

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 98.42%

Cor e Forma: White Powder

Peso molecular: 1143.29

Ref: 01-4033010

3-10-Caerulein, 5-L-methionine-

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 1143.2690

Ref: IN-DA002QKR

Sincalide

CAS: 25126-32-3

Sincalide

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Cor e Forma: Solid-Powder

Peso molecular: 1143.26898

Ref: 54-BITH3042

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Peso molecular: 1143.27

Ref: 7W-GL1683

Sincalide

CAS: 25126-32-3

Sincalide

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: ≥98%

Peso molecular: 1143.27

Ref: 54-BUP02057

Sincalide(CCK-8)

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 1143.27

Ref: BP-BPPG057

Sincalide

CAS: 25126-32-3

Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 98.32%

Cor e Forma: White Viscous

Peso molecular: 1143.27

Ref: TM-TP1197

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

CAS: 25126-32-3

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 is a versatile building block that can be used in research on complex compounds, fine chemicals, speciality chemicals and reagents. It is a high quality chemical that can be used as an intermediate or a scaffold. Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe NH2 is soluble in water and has a high degree of solubility in organic solvents. The compound is also stable under acidic conditions.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 98.0 Area-%

Peso molecular: 1,143.27 g/mol

Ref: 3D-W-107263

Sincalide

CAS: 25126-32-3

Sincalide is a cholecystokinin (CCK) analog that has been used as a pharmacological agent. It is an agonist for CCK-A receptors and inhibits the activity of protein kinase C. Sincalide also has been shown to suppress tumor growth in experimental models. A polymerase chain reaction analysis of cck-8, a rat CCK receptor gene, showed a high degree of homology with human CCK-A receptor genes. The physiological effects of sincalide are complex and depend on the presence or absence of other hormones such as insulin, glucagon, somatostatin, and leptin.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,143.27 g/mol

Ref: 3D-FS41124

CCK-Octapeptide (26-33) (Sulfated Form)

CAS: 25126-32-3

CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 95%

Peso molecular: 1,143.3 g/mol

Ref: 3D-PCK-4100-V

Sincalide

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Peso molecular: 1143.27

Ref: ST-EA-CP-S88000