CAS 25316-40-9
:Cloridrato de doxorrubicina
Descrição:
Cloridrato de doxorrubicina é um antibiótico antraciclínico comumente utilizado na quimioterapia do câncer. É caracterizado por sua cor vermelha brilhante e é conhecido por sua potente atividade antitumoral. O composto atua intercalando o DNA, inibindo assim a síntese de ácidos nucleicos e interrompendo a replicação das células cancerosas. A doxorrubicina é solúvel em água e apresenta um perfil de solubilidade dependente do pH, o que é importante para sua formulação e administração. Seu mecanismo de ação também envolve a geração de radicais livres, contribuindo para seus efeitos citotóxicos. No entanto, o uso de doxorrubicina está associado a vários efeitos colaterais, incluindo cardiotoxicidade, que limita sua dose acumulativa. Geralmente é administrada por via intravenosa e muitas vezes é usada em combinação com outros agentes quimioterápicos para aumentar a eficácia contra várias malignidades, incluindo câncer de mama, leucemia e linfomas. Devido aos seus significativos benefícios terapêuticos e riscos potenciais, o monitoramento e gerenciamento cuidadosos são essenciais durante o tratamento.
Fórmula:C27H29NO11·ClH
InChI:InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Chave InChI:InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Sinónimos:- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- ADM hydrochloride
- ADR
- Adriablastina CS
- Adriacin
- Adriamycin
- Adriamycin, hydrochloride
- Adriblastin
- Adriblastina
- Adriblastina RD
- Adrosal
- Ameisu hydrochloride
- Caelyx pegylated liposomal
- DOX HCl
- Doxolipad
- Doxorubicin, HCl
- Doxorubicin-LANS
- Doxorubicin-TEVA
- Doxourbicin HCl
- Fi 106
- Fi 6804
- Hydroxydaunorubicin hydrochloride
- Lipo-Dox
- Lipodox
- Myocet liposomal
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Doxorubicin Hydrochloride
CAS:Fórmula:C27H29NO11·HClPureza:>95.0%(HPLC)Cor e Forma:Light yellow to Brown powder to crystalPeso molecular:579.98Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.
Fórmula:C27H30ClNO11Cor e Forma:Crystalline powder or granular, Red to orangePeso molecular:579.98DOXORUBICIN HYDROCHLORIDE CRS
CAS:DOXORUBICIN HYDROCHLORIDE CRSFórmula:C27H29NO11Cor e Forma:Crystalline Powder. Orange. Red. Powder.Peso molecular:543.5193Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11HClPureza:99.0%Cor e Forma:Orange To Dark RedPeso molecular:579.15074DOXORUBICIN HYDROCHLORIDE RS
CAS:DOXORUBICIN HYDROCHLORIDE RSFórmula:C27H29NO11Peso molecular:543.5193Doxorubicin Hydrochloride
CAS:Antibiotics nesoiFórmula:C27H29NO11·ClHCor e Forma:Red Orange Crystalline Powder Amorphous PowderPeso molecular:579.15074(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS:Fórmula:C27H30ClNO11Pureza:98%Cor e Forma:SolidPeso molecular:579.9802Ref: IN-DA0035W0
1g120,00€5g535,00€10gA consultar100gA consultar250gA consultar100mg37,00€250mg59,00€Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Fórmula:C27H29NO11·HClPureza:98% - 99.52%Cor e Forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.99Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11·ClHPureza:99%Cor e Forma: orange red crystalline powderPeso molecular:579.98019g/molDoxorubicin hydrochloride, USP grade
CAS:Fórmula:C27H29NO11·HClPureza:≥ 98.0% (anhydrous, solvent-free)Cor e Forma:Orange-red to red crystalline powderPeso molecular:579.99Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS:Fórmula:C27H29NO11·HClCor e Forma:Red SolidPeso molecular:543.53 36.46Doxorubicin hydrochloride, 98%
CAS:Fórmula:C27H29NO11·HClPureza:(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Cor e Forma:Orange-red to red crystalline powderPeso molecular:579.99Doxorubicin Hydrochloride
CAS:Produto ControladoFórmula:C27H29NO11·ClHCor e Forma:NeatPeso molecular:579.98Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Fórmula:C13C22H26D3NO11·HClPeso molecular:547.56 36.45Doxorubicin Hydrochloride
CAS:Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);Fórmula:C27H29NO11·ClHCor e Forma:NeatPeso molecular:579.98Doxorubicin hydrochloride
CAS:Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.Fórmula:C27H29NO11•HClPureza:Min. 95%Peso molecular:579.98 g/mol
![(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihyd…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0035W0.jpg&w=3840&q=75)
