CAS 25812-30-0

gemfibrozila

Descrição:

gemfibrozila é um medicamento utilizado principalmente para reduzir os níveis de lipídios em pacientes com hiperlipidemia, particularmente para reduzir os triglicerídeos e aumentar o colesterol de lipoproteínas de alta densidade (HDL). Pertence à classe de medicamentos conhecidos como fibratos e atua ativando o receptor alfa ativado por proliferadores de peroxissomas (PPARα), o que melhora a oxidação de ácidos graxos e diminui a produção de triglicerídeos no fígado. Quimicamente, gemfibrozila é caracterizado por sua fórmula molecular, que inclui átomos de carbono, hidrogênio e oxigênio, e possui uma configuração estrutural específica que contribui para sua atividade farmacológica. A substância é tipicamente administrada por via oral e é bem absorvida no trato gastrointestinal. Sua farmacocinética envolve um metabolismo extenso no fígado, principalmente através da glucuronidação, e possui uma meia-vida relativamente longa, permitindo a dosagem duas vezes ao dia. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais, e é contraindicado em pacientes com doença hepática ou renal severa. Assim como qualquer medicamento, é essencial monitorar os níveis de lipídios e as potenciais interações medicamentosas durante o tratamento.

Fórmula: C₁₅H₂₂O₃

InChI: InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

Chave InChI: InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES: O(CCCC(C(O)=O)(C)C)C1=C(C)C=CC(C)=C1

Sinónimos:

• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
• 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
• Apo-Gemfibrozil
• Ausgem
• Bolutol
• Brn 1881200
• Brozil
• Ccris 318
• Cholespid
• Ci 719
• Clearol
• Decrelip
• Elmogan
• Fetinor
• Fibratol
• Fibrocit
• Gem-S
• Gemd
• Gemfibril
• Gemfibromax
• Gemfibrozil [USAN:INN:BAN]
• Gemfibrozilo
• Gemfibrozilo [INN-Spanish]
• Gemfibrozilum
• Gemfibrozilum [INN-Latin]
• Gemlipid
• Gemnpid
• Genlip
• Gevilon
• Gevilon Uno
• Gozid
• Hidil
• Hipolixan
• Hsdb 7735
• Innogen
• Ipolipid
• Jezil
• Lanaterom
• Lifibron
• Lipazil
• Lipigem
• Lipira
• Lipizyl
• Lipur
• Litarek
• Lopid
• Lopizid
• Low-Lip
• Micolip
• Normolip
• Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
• Pilder
• Polyxit
• Progemzal
• Reducel
• Regulip
• Renabrazin
• Sinelip
• Synbrozil
• Taborcil
• Tentroc
• Trialmin
• Trialmin 900
• Unii-Q8X02027X3
• Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
• WL-Gemfibrozil
• Gemfibrozil
• 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOICACID(GEMFIBROZIL)
• GEMFIBROZIL,USP
• 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID
• 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoicaci
• 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
• Lipozid
• 2,2-dimethyl-5-(2,5-xylyloxy)-valericaci
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
• Gemcitabine intermediates
• 5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
• 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
• CI-7

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: >98.0%(GC)(T)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 250.34

Ref: 3B-G0368

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

CAS: 25812-30-0

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: 41-Y0000514

GEMFIBROZIL CRS

CAS: 25812-30-0

GEMFIBROZIL CRS

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Added Modified

Peso molecular: 250.3334

Ref: 41-Y0000513

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: 99.9%

Cor e Forma: White Solid

Peso molecular: 250.15689

Ref: 47-363

Gemfibrozil

CAS: 25812-30-0

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Off-White White Powder

Peso molecular: 250.15689

Ref: 45-1288500

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.

Fórmula: C₁₅H₂₂O₃

Pureza: 99.53% - 99.88%

Cor e Forma: Crystals From Hexane Solid

Peso molecular: 250.3334

Ref: TM-T1415

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 250.33

Ref: 54-OR1029081

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: ≥98%

Peso molecular: 250.33

Ref: 54-BUP14848

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: ≥ 98.0% (anhydrous basis)

Cor e Forma: White crystalline powder

Peso molecular: 250.33

Ref: 7W-GP1460

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 250.34

Ref: 4Z-G-1211

Gemfibrozil (Standard)

CAS: 25812-30-0

Gemfibrozil (Standard) is the standard substance of Gemfibrozil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: TM-TMSM-1256

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Neat

Peso molecular: 250.33

Ref: 04-C13999000

Pharmaceuticals Mixture 327 200 µg/mL in Methanol

Produto Controlado

CAS: 15687-27-1, 22204-53-1, 25812-30-0, 3380-34-5

Cor e Forma: Mixture

Ref: 04-A50000327ME

Gemfibrozil

Produto Controlado

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Neat

Peso molecular: 250.33

Ref: 86-MM0641.00

Gemfibrozil 100 µg/mL in Acetonitrile

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Single Solution

Peso molecular: 250.33

Ref: 04-A13999000AL-100

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 250.3334

Ref: IN-DA0034YR

Gemfibrozil

Produto Controlado

CAS: 25812-30-0

Applications A serum lipid regulating agent used as an antihyperlipoproteinemic.This compound is a contaminant of emerging concern (CECs).
References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Fórmula: C₁₅H₂₂O₃

Cor e Forma: Neat

Peso molecular: 250.33

Ref: TR-G305750

Gemfibrozil

CAS: 25812-30-0

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Peso molecular: 250.33

Ref: IN-DG32912

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.34

Ref: ST-EA-CP-G25000

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil is a chemical inhibitor that inhibits the response element to the transcription factor PPAR-α. It has been shown to decrease cardiac effects such as increased heart rate, stroke volume, and cardiac output. Gemfibrozil has been used for wastewater treatment and has been found to be an analytical method for determining the concentration of other drugs in urine. The ecological effects of gemfibrozil are not well understood, but it is known that it can cause adverse effects on locomotor activity in animals. Gemfibrozil is a potent inducer of liver enzymes and may interact with other drugs by increasing their concentration time curve. This drug also has oral hypoglycemic properties, which lowers the blood glucose level by stimulating insulin production.

Fórmula: C₁₅H₂₂O₃

Pureza: Min. 95%

Peso molecular: 250.33 g/mol

Ref: 3D-FD23652