CAS 2595308-10-2

Fórmula: C26H30FN5O4S

InChI: InChI=1S/C26H30FN5O4S/c1-15(2)28-8-9-36-24-21(31-37(4,34)35)10-16(13-30-24)17-11-18-20(12-19(17)27)29-14-22-23(18)26(6-5-7-26)25(33)32(22)3/h10-15,28,31H,5-9H2,1-4H3

Chave InChI: DFPIFDHNNWOIDD-UHFFFAOYSA-N

SMILES: CC(C)NCCOC1=C(C=C(C=N1)C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)C45CCC5)C)F)NS(=O)(=O)C

XRD-0394

CAS: 2595308-10-2

XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro ^[1].

Fórmula: C₂₆H₃₀FN₅O₄S

Peso molecular: 527.61

Ref: TM-T87647