CAS 2651196-71-1

Fórmula: C20H21F2N9

InChI: InChI=1S/C20H21F2N9/c21-13-3-4-14-17(16(13)22)27-15(26-14)10-24-19-29-20(30-7-5-23-6-8-30)28-18-12(11-1-2-11)9-25-31(18)19/h3-4,9,11,23H,1-2,5-8,10H2,(H,26,27)(H,24,28,29)

Chave InChI: BQWUTZRKMIAITL-UHFFFAOYSA-N

SMILES: C1CC1C2=C3N=C(N=C(N3N=C2)NCC4=NC5=C(N4)C=CC(=C5F)F)N6CCNCC6

CDK12-IN-6

CAS: 2651196-71-1

CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).

Fórmula: C₂₀H₂₁F₂N₉

Cor e Forma: Solid

Peso molecular: 425.448

Ref: TM-T40289