CAS 2803921-87-9

Fórmula: C25H25Cl2N7O

InChI: InChI=1S/C25H25Cl2N7O/c1-31-8-6-16(7-9-31)34-13-15(11-29-34)21-10-17-22-18(12-28-24(17)30-21)25(35)33(14-32(22)2)23-19(26)4-3-5-20(23)27/h3-5,10-13,16H,6-9,14H2,1-2H3,(H,28,30)

Chave InChI: VJOVQNRPBNUNAA-UHFFFAOYSA-N

SMILES: CN1CCC(CC1)N2C=C(C=N2)C3=CC4=C5C(=CN=C4N3)C(=O)N(CN5C)C6=C(C=CC=C6Cl)Cl

WEE1-IN-14

CAS: 2803921-87-9

WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor, with an IC₅₀ of 0.5 nM determined by L-RB-FEP calculations and 1.0 nM in ADP-Glo​​ kinase assays. Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removing cell cycle regulation, leading to premature mitotic failure and subsequent tumor cell apoptosis. Thus, WEE1-IN-14 serves as a valuable tool for studying cancer biology.

Fórmula: C₂₅H₂₅Cl₂N₇O

Peso molecular: 510.42

Ref: TM-T213275